Introduction：Basic information about CAS 125697-92-9|lavendustin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | lavendustin A |
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| CAS Number | 125697-92-9 | Molecular Weight | 381.37900 |
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| Density | / | Boiling Point | 741.7ºC at 760 mmHg |
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| Molecular Formula | C21H19NO6 | Melting Point | 205-215 °C |
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| MSDS | / | Flash Point | 402.4ºC |
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Names
| Name | lavendustin a |
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| Synonym | More Synonyms |
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lavendustin A BiologicalActivity
| Description | Lavendustin A (RG-14355), isolated from Streptomyces Griseolavendus, is a potent, specific and ATP-competitive inhibitor of tyrosine kinase, with an IC50 of 11 ng/mL for EGFR-associated tyrosine kinase[1]. It suppresses VEGF-induced angiogenesis and blocks the induction of LTPGABA-A[2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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| Target | IC50: 11 ng/mL (EGFR-associated tyrosine kinase)[1]. |
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| References | [1]. Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7. [2]. Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. [3]. Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802. |
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Chemical & Physical Properties
| Boiling Point | 741.7ºC at 760 mmHg |
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| Melting Point | 205-215 °C |
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| Molecular Formula | C21H19NO6 |
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| Molecular Weight | 381.37900 |
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| Flash Point | 402.4ºC |
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| Exact Mass | 381.12100 |
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| PSA | 121.46000 |
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| LogP | 3.41400 |
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| Appearance of Characters | crystalline |
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| Vapour Pressure | 4.23E-23mmHg at 25°C |
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| InChIKey | ULTTYPMRMMDONC-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(N(Cc2ccccc2O)Cc2cc(O)ccc2O)ccc1O |
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| Storage condition | −20°C |
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| Stability | Moisture Sensitive: Hygroscopic |
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| Water Solubility | DMSO: soluble |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S37/39-S26 |
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| WGK Germany | 3 |
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Synonyms
| MFCD00153822 |
| Lavendustin A |
| 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid |
| 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid |
