CAS 304909-07-7|SANT-1
| Common Name | SANT-1 | ||
|---|---|---|---|
| CAS Number | 304909-07-7 | Molecular Weight | 373.49 |
| Density | 1.13g/cm3 | Boiling Point | 547.4ºC at 760mmHg |
| Molecular Formula | C23H27N5 | Melting Point | 104-106ºC |
| MSDS | ChineseUSA | Flash Point | 284.8ºC |
Names
| Name | (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine |
|---|---|
| Synonym | More Synonyms |
SANT-1 BiologicalActivity
| Description | SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>SmoResearch Areas >>CancerSignaling Pathways >>Stem Cell/Wnt >>Hedgehog |
| Target | IC50: 20 nM (Shh signaling), 30 nM (SmoA1)[1] |
| References | [1]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. |
Chemical & Physical Properties
| Density | 1.13g/cm3 |
|---|---|
| Boiling Point | 547.4ºC at 760mmHg |
| Melting Point | 104-106ºC |
| Molecular Formula | C23H27N5 |
| Molecular Weight | 373.49 |
| Flash Point | 284.8ºC |
| Exact Mass | 373.22700 |
| PSA | 36.66000 |
| LogP | 3.51660 |
| Index of Refraction | 1.623 |
| InChIKey | FOORCIAZMIWALX-ULJHMMPZSA-N |
| SMILES | Cc1nn(-c2ccccc2)c(C)c1C=NN1CCN(Cc2ccccc2)CC1 |
| Storage condition | −20°C |
| Water Solubility | Soluble in DMSO with warming |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles13
More Articles| Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 4(4) , e5182, (2009) Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up... | |
| MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. Arthritis Rheumatology 67(2) , 423-34, (2015) Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1β (IL-1β) has been implicated as a principal instigator of OA, we sought to... | |
| MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 29 , 1817-29, (2015) The Smoothened (Smo) receptor, a member of class F G protein-coupled receptors, is the main transducer of the Hedgehog (Hh) signaling pathway implicated in a wide range of developmental and adult proc... |
Synonyms
| (E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine |
| SANT-1 |
| (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
| Shh Signaling Antagonist V |
| (E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine |
| 1-Piperazinamine (N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl) |
| 1-Piperazinamine, N-[(1E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- |
