Introduction：Basic information about CAS 95094-00-1|(S)-(-)-Carvedilol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-(-)-Carvedilol |
|---|
| CAS Number | 95094-00-1 | Molecular Weight | 406.47400 |
|---|
| Density | 1.25 g/cm3 | Boiling Point | 655.2ºC at 760 mmHg |
|---|
| Molecular Formula | C24H26N2O4 | Melting Point | 114-115ºC |
|---|
| MSDS | / | Flash Point | 350.1ºC |
|---|
Names
| Name | (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol |
|---|
| Synonym | More Synonyms |
|---|
(S)-(-)-Carvedilol BiologicalActivity
| Description | (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
|---|
| Target | β/α-1 adrenergic receptor[1] |
|---|
| In Vitro | The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1]. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1]. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1]. |
|---|
| References | [1]. Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. |
|---|
Chemical & Physical Properties
| Density | 1.25 g/cm3 |
|---|
| Boiling Point | 655.2ºC at 760 mmHg |
|---|
| Melting Point | 114-115ºC |
|---|
| Molecular Formula | C24H26N2O4 |
|---|
| Molecular Weight | 406.47400 |
|---|
| Flash Point | 350.1ºC |
|---|
| Exact Mass | 406.18900 |
|---|
| PSA | 75.74000 |
|---|
| LogP | 4.12890 |
|---|
| InChIKey | OGHNVEJMJSYVRP-KRWDZBQOSA-N |
|---|
| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
|---|
| Storage condition | 2-8°C |
|---|
Synonyms
| UNII-0K47UL67F2 component OGHNVEJMJSYVRP-KRWDZBQOSA-N |
| (S)-(-)-Carvedilol |
| Carvedilol Impurity 11 |
