Introduction：Basic information about CAS 150403-89-7|L-NIL hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-NIL hydrochloride |
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| CAS Number | 150403-89-7 | Molecular Weight | 260.16100 |
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| Density | / | Boiling Point | 369ºC at 760 mmHg |
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| Molecular Formula | C8H19Cl2N3O2 | Melting Point | 253-255ºC |
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| MSDS | / | Flash Point | 177ºC |
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Names
| Name | l-n6-(1-iminoethyl)lysine dihydrochloride |
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| Synonym | More Synonyms |
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L-NIL hydrochloride BiologicalActivity
| Description | L-NIL hydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[1]. |
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| In Vitro | L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[3]. |
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| In Vivo | L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1]. Animal Model: Adult male Balb/c (20-25 g)[1]. Dosage: 10 and 30 mg/kg. Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction. Result: Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle. |
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| References | [1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [3]. Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. |
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Chemical & Physical Properties
| Boiling Point | 369ºC at 760 mmHg |
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| Melting Point | 253-255ºC |
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| Molecular Formula | C8H19Cl2N3O2 |
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| Molecular Weight | 260.16100 |
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| Flash Point | 177ºC |
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| Exact Mass | 259.08500 |
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| PSA | 99.20000 |
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| LogP | 2.95030 |
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| Vapour Pressure | 1.86E-06mmHg at 25°C |
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| InChIKey | HJYWSATZDBEAOS-FJXQXJEOSA-N |
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| SMILES | CC(N)=NCCCCC(N)C(=O)O.Cl |
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| Storage condition | −20°C |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 3 |
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Synonyms
| l-nil dihydrochloride |
| l-nil hcl |
| l-nil hydrochloride |
| l-nil |
| MFCD00270890 |
