CAS 35795-16-5|Trimazosin
Introduction：Basic information about CAS 35795-16-5|Trimazosin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimazosin | ||
|---|---|---|---|
| CAS Number | 35795-16-5 | Molecular Weight | 435.47 |
| Density | 1.31g/cm3 | Boiling Point | 648.2ºC at 760mmHg |
| Molecular Formula | C20H29N5O6 | Melting Point | / |
| MSDS | / | Flash Point | 345.8ºC |
Names
| Name | (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate |
|---|---|
| Synonym | More Synonyms |
Trimazosin BiologicalActivity
| Description | Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | α1-adrenergic receptor |
| In Vivo | Trimazosin (10–30 mg/kg; i.h.; once) produces graded decreases in blood pressure[3]. Animal Model: Conscious spontaneously hypertensive rats (SHR)[3] Dosage: 10–30 mg/kg Administration: Subcutaneous administration, once Result: Produced graded decreases in blood pressure. |
| References | [1]. J Vincent, et al. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608. [2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60. [3]. J. P. Buyniski, et al. Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension , 1980, Vol.2(6), p.1039-1066. |
Chemical & Physical Properties
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 648.2ºC at 760mmHg |
| Molecular Formula | C20H29N5O6 |
| Molecular Weight | 435.47 |
| Flash Point | 345.8ºC |
| Exact Mass | 435.21200 |
| PSA | 132.50000 |
| LogP | 1.85140 |
| Index of Refraction | 1.606 |
| InChIKey | YNZXWQJZEDLQEG-UHFFFAOYSA-N |
| SMILES | COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC |
Synonyms
| trimazosine |
| TRIMAZOSIN |
| EINECS 252-732-7 |
