Introduction：Basic information about CAS 67452-97-5|Alclometasone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alclometasone |
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| CAS Number | 67452-97-5 | Molecular Weight | 408.91600 |
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| Density | 1.34g/cm3 | Boiling Point | 607.1ºC at 760mmHg |
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| Molecular Formula | C22H29ClO5 | Melting Point | / |
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| MSDS | / | Flash Point | 320.9ºC |
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Names
| Name | alclometasone |
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| Synonym | More Synonyms |
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Alclometasone BiologicalActivity
| Description | Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor |
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| Target | IC50: glucocorticoid receptor[1] |
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| In Vivo | The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
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| References | [1]. Alclometasone [2]. Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50(4):435-43. |
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Chemical & Physical Properties
| Density | 1.34g/cm3 |
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| Boiling Point | 607.1ºC at 760mmHg |
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| Molecular Formula | C22H29ClO5 |
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| Molecular Weight | 408.91600 |
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| Flash Point | 320.9ºC |
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| Exact Mass | 408.17000 |
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| PSA | 94.83000 |
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| LogP | 2.02090 |
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| Index of Refraction | 1.607 |
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| InChIKey | FJXOGVLKCZQRDN-PHCHRAKRSA-N |
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| SMILES | CC1CC2C3C(Cl)CC4=CC(=O)C=CC4(C)C3C(O)CC2(C)C1(O)C(=O)CO |
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Safety Information
Customs
Synonyms
| (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| alcometasone |
| 136H45TB7B |
| 7alpha-Chloro-16alpha-methylprednisolone |
| UNII-136H45TB7B |
| Alclomethasone |
| Aclometasone |
