Introduction：Basic information about CAS 91-81-6|Tripelennamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tripelennamine |
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| CAS Number | 91-81-6 | Molecular Weight | 255.35800 |
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| Density | 1.0683 (rough estimate) | Boiling Point | 185 - 190ºC at 1.7 mm Hg |
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| Molecular Formula | C16H21N3 | Melting Point | 25°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine |
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| Synonym | More Synonyms |
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Tripelennamine BiologicalActivity
| Description | Tripelennamine, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine lessens the allergic response of the organism caused by histamine. Tripelennamine can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>EndocrinologyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H1 Receptor |
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| References | [1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23. [2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52. [3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76. |
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Chemical & Physical Properties
| Density | 1.0683 (rough estimate) |
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| Boiling Point | 185 - 190ºC at 1.7 mm Hg |
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| Melting Point | 25°C |
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| Molecular Formula | C16H21N3 |
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| Molecular Weight | 255.35800 |
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| Exact Mass | 255.17400 |
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| PSA | 19.37000 |
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| LogP | 2.64980 |
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| Index of Refraction | nD25 1.5759-1.5765 |
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| InChIKey | UFLGIAIHIAPJJC-UHFFFAOYSA-N |
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| SMILES | CN(C)CCN(Cc1ccccc1)c1ccccn1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- US2800000
- CHEMICAL NAME :
- Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
- CAS REGISTRY NUMBER :
- 91-81-6
- BEILSTEIN REFERENCE NO. :
- 0227074
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C16-H21-N3
- MOLECULAR WEIGHT :
- 255.40
- WISWESSER LINE NOTATION :
- T6NJ BN1R&2N1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 61 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Human Liver
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)
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Synonyms
| Piribenzil |
| Tonaril |
| N-benzyl-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine |
| Benzoxale |
| Tripelennamin |
| Pyribenzamine |
| Cizaron |
| N-benzyl-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine |
| Resistamine |
| tripelenamin |
| Tripelennamina |
| tripelennamine |
| Pyrinamine base |
