Introduction：Basic information about CAS 148-56-1|2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide |
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| CAS Number | 148-56-1 | Molecular Weight | 329.27600 |
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| Density | 1.99g/cm3 | Boiling Point | 560ºC at 760mmHg |
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| Molecular Formula | C8H6F3N3O4S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1,1-dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.99g/cm3 |
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| Boiling Point | 560ºC at 760mmHg |
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| Molecular Formula | C8H6F3N3O4S2 |
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| Molecular Weight | 329.27600 |
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| Exact Mass | 328.97500 |
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| PSA | 135.45000 |
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| LogP | 2.93080 |
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| Index of Refraction | 1.673 |
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| InChIKey | RGUQWGXAYZNLMI-UHFFFAOYSA-N |
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| SMILES | NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC=NS2(=O)=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DK9800000
- CHEMICAL NAME :
- 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 148-56-1
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H6-F3-N3-O4-S2
- MOLECULAR WEIGHT :
- 329.29
- WISWESSER LINE NOTATION :
- T66 BSWM ENJ HXFFF ISZW
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1760 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 910 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,405,1960
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Safety Information
Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| Trifluoromethylthiazide |
| Flumethazide |
| Trifluomethylthiazide |
| Fludemil |
| Ademol |
| Ademil |
| Flumetiazid |
| EINECS 205-717-4 |
| 6-Trifluormethyl-7-sulfamoyl-2H-benzo-1,2,4-thiadiazol-S,S-dioxid |
| 6-trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide |
| Flumethiazid |
| 7-Sulfamoyl-6-trifluormethyl-1,2,4-benzothiadiazin-dioxid-(1,1) |
| Routrax |
| Flumethiazide |
