Introduction：Basic information about CAS 576-68-1|mannomustine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | mannomustine |
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| CAS Number | 576-68-1 | Molecular Weight | 305.19900 |
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| Density | 1.353g/cm3 | Boiling Point | 541.9ºC at 760 mmHg |
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| Molecular Formula | C10H22Cl2N2O4 | Melting Point | 278°C (rough estimate) |
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| MSDS | / | Flash Point | 281.5ºC |
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Names
| Name | (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.353g/cm3 |
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| Boiling Point | 541.9ºC at 760 mmHg |
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| Melting Point | 278°C (rough estimate) |
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| Molecular Formula | C10H22Cl2N2O4 |
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| Molecular Weight | 305.19900 |
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| Flash Point | 281.5ºC |
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| Exact Mass | 304.09600 |
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| PSA | 104.98000 |
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| Index of Refraction | 1.544 |
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| InChIKey | MQXVYODZCMMZEM-ZYUZMQFOSA-N |
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| SMILES | OC(CNCCCl)C(O)C(O)C(O)CNCCCl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OP2100000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,
- CAS REGISTRY NUMBER :
- 576-68-1
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4
- MOLECULAR WEIGHT :
- 305.24
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G -D
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Cells - not otherwise specified
- DOSE/DURATION :
- 2900 nmol/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982
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Synonyms
| Mannit-lost [German] |
| Mannomustin |
| Mannitol nitrogen mustard |
| Manomustina [INN-Spanish] |
| Mannomustine [INN:BAN:DCF] |
| Mannit-mustard [German] |
| Mannit-Lost |
| Mannomustinum [INN-Latin] |
| 1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol |
| 1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit |
| BCM (cytostatic) |
| mannomustine |
| 1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol |
| 1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit |
