Introduction：Basic information about CAS 126222-34-2|Remikiren, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Remikiren |
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| CAS Number | 126222-34-2 | Molecular Weight | 630.83800 |
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| Density | 1.241g/cm3 | Boiling Point | 970.2ºC at 760mmHg |
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| Molecular Formula | C33H50N4O6S | Melting Point | / |
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| MSDS | / | Flash Point | 540.6ºC |
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Names
| Name | Remikiren |
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| Synonym | More Synonyms |
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Remikiren BiologicalActivity
| Description | Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Renin |
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| Target | IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1]. |
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| In Vitro | Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1]. Cell Viability Assay[1] Cell Line: Human pure renin, plasma renin of human, marmoset, squirrel monkey Concentration: 0-10 nM Incubation Time: 1-3 h Result: Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC50 values of 0.7, 0.8, 1.0 and 1.7 nM, respectively. |
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| In Vivo | Remikiren (0.1, 0.3, 1, 3, 10 mg/kg; p.o.; single) reduces mean arterial blood pressure in a dose-dependent manner in sodium-depleted marmosets and squirrel monkeys[1]. Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1]. Animal Model: Marmosets and squirrel monkeys (sodium-depleted)[1]. Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: Oral administration; single. Result: Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg. Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets. Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys. Animal Model: Marmosets (sodium-depleted)[1]. Dosage: 3 mg/kg Administration: Oral administration; single. Result: Showed MAP fell by 30 mm Hg, which lasting more than 24 h. |
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Chemical & Physical Properties
| Density | 1.241g/cm3 |
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| Boiling Point | 970.2ºC at 760mmHg |
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| Molecular Formula | C33H50N4O6S |
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| Molecular Weight | 630.83800 |
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| Flash Point | 540.6ºC |
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| Exact Mass | 630.34500 |
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| PSA | 169.86000 |
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| LogP | 4.95880 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.581 |
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| InChIKey | UXIGZRQVLGFTOU-VQXQMPIVSA-N |
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| SMILES | CC(C)(C)S(=O)(=O)CC(Cc1ccccc1)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC1CCCCC1)C(O)C(O)C1CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NI8252250
- CHEMICAL NAME :
- 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypr opyl)- alpha-((2-(((1,1-dimethylethyl)sulfonyl)methyl)-1-oxo -3-phenylpropyl)amino )-, (1S-(1R*(R*(R*)),2S*,3R*))-
- CAS REGISTRY NUMBER :
- 126222-34-2
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C33-H50-N4-O6-S
- MOLECULAR WEIGHT :
- 630.93
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 53,585,1993
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Synonyms
