CAS 30045-16-0|Dehydrocorydalin
Introduction：Basic information about CAS 30045-16-0|Dehydrocorydalin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dehydrocorydalin | ||
|---|---|---|---|
| CAS Number | 30045-16-0 | Molecular Weight | 366.43000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C22H24NO4+ | Melting Point | 170-173℃ |
| MSDS | / | Flash Point | / |
Names
| Name | Dehydrocorydaline |
|---|---|
| Synonym | More Synonyms |
Dehydrocorydalin BiologicalActivity
| Description | Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Cell Cycle/DNA Damage >>PARPSignaling Pathways >>Epigenetics >>PARPNatural Products >>AlkaloidResearch Areas >>Cancer |
| Target | Bcl-2 Bax Caspase-7 Caspase-8 PARP |
| In Vitro | Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline[1]. Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression[1]. Dehydrocorydaline (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9[1]. |
| In Vivo | Dehydrocorydaline manifests a low acute toxicity with an LD50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection[2]. |
| References | [1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. [2]. Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129. |
Chemical & Physical Properties
| Melting Point | 170-173℃ |
|---|---|
| Molecular Formula | C22H24NO4+ |
| Molecular Weight | 366.43000 |
| Exact Mass | 366.17100 |
| PSA | 40.80000 |
| LogP | 3.69320 |
| InChIKey | RFKQJTRWODZPHF-UHFFFAOYSA-N |
| SMILES | COc1cc2c(cc1OC)-c1c(C)c3ccc(OC)c(OC)c3c[n+]1CC2 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 78 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 84,73,1964
Safety Information
| HS Code | 2933990090 |
|---|
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| dehydrocorydalmine |
| dehydeocorydaline |
| 5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium |
| 2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydro-isochino[3,2-a]isochinolinylium |
| Dehydrocorydalin |
| 13-Methyl-2,3,9,10-tetramethoxy-5,6-dihydrodibenzo[a,g]quinolizinium |
| 13-methylpalmatine |
| 2,3,9,10-tetramethoxy-13-methyl-5,6-dihydro-isoquino[3,2-a]isoquinolinylium |
