Introduction：Basic information about CAS 51020-87-2|Licarin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licarin B |
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| CAS Number | 51020-87-2 | Molecular Weight | 324.370 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 428.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H20O4 | Melting Point | / |
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| MSDS | / | Flash Point | 131.4±35.6 °C |
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Names
| Name | 5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole |
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| Synonym | More Synonyms |
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Licarin B BiologicalActivity
| Description | Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
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| In Vitro | Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes[2]. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. |
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| References | [1]. Kim YB, et al. The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res. 1991 Mar;14(1):1-6. [2]. G. L. Shyni, et al. Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes. RSC Adv. 2016. [3]. Cao GY, et al. New inhibitors of nitric oxide production from the seeds of Myristica fragrans. Food Chem Toxicol. 2013 Dec;62:167-71. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 428.5±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H20O4 |
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| Molecular Weight | 324.370 |
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| Flash Point | 131.4±35.6 °C |
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| Exact Mass | 324.136169 |
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| PSA | 36.92000 |
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| LogP | 5.08 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.608 |
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| InChIKey | DMMQXURQRMNSBM-YZAYTREXSA-N |
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| SMILES | CC=Cc1cc(OC)c2c(c1)C(C)C(c1ccc3c(c1)OCO3)O2 |
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| Storage condition | 2-8C |
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Synonyms
| 5-{(2R,3R)-7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran-2-yl}-1,3-benzodioxole |
| Eupomatenoid-8 |
| 1,3-Benzodioxole, 5-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2-benzofuranyl]- |
| (-)-Licarin B |
| 5-{(2R,3R)-7-Methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2,3-dihydro-1-benzofuran-2-yl}-1,3-benzodioxole |
