Introduction：Basic information about CAS 112559-91-8|Hydroxy Itraconazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxy Itraconazole |
|---|
| CAS Number | 112559-91-8 | Molecular Weight | 721.63 |
|---|
| Density | 1.44g/cm3 | Boiling Point | 884.7ºC at 760mmHg |
|---|
| Molecular Formula | C35H38Cl2N8O5 | Melting Point | 76-78ºC |
|---|
| MSDS | / | Flash Point | 488.8ºC |
|---|
Names
| Name | Hydroxy Itraconazole |
|---|
| Synonym | More Synonyms |
|---|
Hydroxy Itraconazole BiologicalActivity
| Description | Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent. |
|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Others |
|---|
| Target | Antifungal[1] |
|---|
| In Vitro | Hydroxy Itraconazole (OH-ITZ) is an active metabolite of Itraconazole (ITZ). Although OH-ITZ is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and OH-ITZ have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration[1]. |
|---|
| In Vivo | The plasma concentration of OH-ITZ is weakly dependent on the dose of ITZ, most likely because the process that forms OH-ITZ is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and OH-ITZ. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of OH-ITZ. However, the pharmacokinetics of OH-ITZ is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and OH-ITZ are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view[1]. |
|---|
| References | [1]. Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32. |
|---|
Chemical & Physical Properties
| Density | 1.44g/cm3 |
|---|
| Boiling Point | 884.7ºC at 760mmHg |
|---|
| Melting Point | 76-78ºC |
|---|
| Molecular Formula | C35H38Cl2N8O5 |
|---|
| Molecular Weight | 721.63 |
|---|
| Flash Point | 488.8ºC |
|---|
| PSA | 103.95000 |
|---|
| LogP | 4.96710 |
|---|
| Vapour Pressure | 0mmHg at 25°C |
|---|
| Index of Refraction | 1.687 |
|---|
| InChIKey | ISJVOEOJQLKSJU-UHFFFAOYSA-N |
|---|
| SMILES | CC(O)C(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| Itraconazole metabolite Hydroxy Itraconazole |
