Introduction：Basic information about CAS 149-87-1|5-Oxopyrrolidine-2-carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Oxopyrrolidine-2-carboxylic acid |
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| CAS Number | 149-87-1 | Molecular Weight | 129.114 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 453.1±38.0 °C at 760 mmHg |
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| Molecular Formula | C5H7NO3 | Melting Point | 180-185ºC |
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| MSDS | ChineseUSA | Flash Point | 227.8±26.8 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 5-oxoproline |
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| Synonym | More Synonyms |
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5-Oxopyrrolidine-2-carboxylic acid BiologicalActivity
| Description | DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| In Vitro | DL-Pyroglutamic acid results 50 and 100% inactivation of the antigen of 0.01-0.025% and 0.025-0.05%, respectively[1]. DL-Pyroglutamic acid is a possible glutamate antagonist, blocks glutamate miniature-end-plate potential in locust muscle-Druce and Bradford[2]. |
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| In Vivo | DL-Pyroglutamic acid (0.775 mM/L) completely abolishes the myoclonic jerks and EEG spikes in rats model of epileptic by cobalt implantation in the sensorimotor cerebral cortex[2]. |
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| References | [1]. Sugimoto Y, et al. N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen. Antimicrob Agents Chemother. 1979 Sep;16(3):329-32. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 453.1±38.0 °C at 760 mmHg |
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| Melting Point | 180-185ºC |
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| Molecular Formula | C5H7NO3 |
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| Molecular Weight | 129.114 |
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| Flash Point | 227.8±26.8 °C |
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| Exact Mass | 129.042587 |
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| PSA | 66.40000 |
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| LogP | -2.39 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.512 |
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| InChIKey | ODHCTXKNWHHXJC-UHFFFAOYSA-N |
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| SMILES | O=C1CCC(C(=O)O)N1 |
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| Water Solubility | 5.67 g/100 mL (20 ºC) |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi:Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S37/39 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 29337900 |
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Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Articles1
More Articles
| Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine. Talanta 132 , 1-7, (2014) In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic ... | |
Synonyms
| MFCD00064322 |
| L-Pidolic acid |
| H-DL-Pyr-OH |
| DL-2-Pyrrolidone-5-carboxylic acid |
| (S)-(-)-2-pyrrolidone-5-carboxylic acid |
| Ajidew A 100 |
| Pyrrolidonecarboxylic acid |
| (S)-(-)-γ-Butyrolactam-γ-carboxylic acid |
| PyroGlu |
| L-Proline, 5-oxo- |
| 5-Oxopyrrolidine-2-carboxylic Acid |
| Pyroglutamic acid |
| 2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-hydroxy-, (2S)- |
| L-5-Oxoproline |
| DL-Pyroglutamic acid |
| (S)-(−)-Pyroglutamic acid |
| a-Aminoglutaric Acid Lactam |
| 5-oxo-proline |
| (S)-(−)-2-Pyrrolidone-5-carboxylic acid |
| (-)-Pyroglutamic acid |
| L-Glutamic Acid g-Lactam |
| 5-Oxo-L-proline |
| 5-Pyrrolidinone-2-carboxylic acid |
| D,l-2-Pyrrolidone-5-Carboxylic Acid |
| Proline, 5-oxo-, L- |
| PCA |
| Glutamic Acid Lactam |
| 2-L-Pyrrolidone-5-carboxylic acid |
| pidolic acid |
| EINECS 205-748-3 |
| (2S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid |
| DL-Glutamic Acid Lactam |
| 5-L-oxoproline |
| 2-Pyrrolidone-5-carboxylic acid |
| (S)-(-)-g-Butyrolactam-g-carboxylic Acid |
