Introduction：Basic information about CAS 5985-28-4|Synephrine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Synephrine hydrochloride |
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| CAS Number | 5985-28-4 | Molecular Weight | 203.666 |
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| Density | / | Boiling Point | 341.1ºC at 760 mmHg |
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| Molecular Formula | C9H14ClNO2 | Melting Point | 147-150ºC |
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| MSDS | / | Flash Point | 163.4ºC |
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Names
| Name | 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride |
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| Synonym | More Synonyms |
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Synephrine hydrochloride BiologicalActivity
| Description | Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorNatural Products >>AlkaloidResearch Areas >>Neurological Disease |
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| References | [1]. Synephrine, From Wikipedia |
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Chemical & Physical Properties
| Boiling Point | 341.1ºC at 760 mmHg |
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| Melting Point | 147-150ºC |
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| Molecular Formula | C9H14ClNO2 |
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| Molecular Weight | 203.666 |
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| Flash Point | 163.4ºC |
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| Exact Mass | 203.071304 |
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| PSA | 52.49000 |
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| LogP | 1.83790 |
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| InChIKey | COTCEGYSNTWJQV-UHFFFAOYSA-N |
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| SMILES | CNCC(O)c1ccc(O)cc1.Cl |
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| Storage condition | Refrigerator |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DO7700000
- CHEMICAL NAME :
- Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 5985-28-4
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H13-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 203.69
- WISWESSER LINE NOTATION :
- QR DYQ1M1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2922199090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| UNII:EN5D1IH09S |
| DL-synephrine hydrochloride |
| EINECS 227-804-6 |
| Synephrine HCl |
| 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride |
| MFCD00050566 |
| Synephrine hydrochloride |
| 4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1) |
| 2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride |
| Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1) |
| (+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride |
| Oxedrine hydrochloride |
| Ocuton (TN) |
| 1-(4-Hydroxy-phenyl)-2-methylamino-aethanol,Hydrochlorid |
