Introduction：Basic information about CAS 51-40-1|Noradrenaline tartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Noradrenaline tartrate |
|---|
| CAS Number | 51-40-1 | Molecular Weight | 319.265 |
|---|
| Density | / | Boiling Point | 442.6ºC at 760 mmHg |
|---|
| Molecular Formula | C12H17NO9 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 221.5ºC |
|---|
Names
| Name | l-Noradrenaline tartrate |
|---|
| Synonym | More Synonyms |
|---|
Noradrenaline tartrate BiologicalActivity
| Description | Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
|---|
| Target | EC50: 5.37 μM (β1-selective adrenergic receptor)[1]. |
|---|
| In Vitro | Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment[2]. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. RT-PCR[2] Cell Line: Subcutaneous preadipocytes Adipocytes. Concentration: 10 μM. Incubation Time: 6 hours. Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA) |
|---|
| References | [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. |
|---|
Chemical & Physical Properties
| Boiling Point | 442.6ºC at 760 mmHg |
|---|
| Molecular Formula | C12H17NO9 |
|---|
| Molecular Weight | 319.265 |
|---|
| Flash Point | 221.5ºC |
|---|
| Exact Mass | 319.090332 |
|---|
| PSA | 201.77000 |
|---|
| InChIKey | WNPNNLQNNJQYFA-YIDNRZKSSA-N |
|---|
| SMILES | NCC(O)c1ccc(O)c(O)c1.O=C(O)C(O)C(O)C(=O)O |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DN6750000
- CAS REGISTRY NUMBER :
- 51-40-1
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C8-H11-N-O3.C4-H6-O6
- MOLECULAR WEIGHT :
- 319.30
- WISWESSER LINE NOTATION :
- Z1YQR CQ DQ &OVYQYQVO
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3987 ug/kg
- TOXIC EFFECTS :
- Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 26800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1025 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5302 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)
|
Safety Information
| Hazard Codes | T+ |
|---|
| Safety Phrases | S22-S24/25 |
|---|
| RIDADR | UN 3249 |
|---|
| Packaging Group | III |
|---|
| Hazard Class | 6.1(b) |
|---|
| HS Code | 2922210000 |
|---|
Customs
| HS Code | 2922509090 |
|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| Norepinephrine Bitartrate |
| l-noradrenalinetartrate |
| noradrenaline bitartrate |
| Levarterenolbitartrate |
| MFCD00036384 |
| 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1) |
| Leverterenol bitartrate |
| noradrenalinetartrate |
| 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1) |
| 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt) |
| L-ARTERENOL BITARTRATE |
| Noradrenalineacidtartrate |
| 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1) |
| NORADRENALINE |
| EINECS 200-095-0 |
| Levoarterenol bitartrate |
