CAS 1178-24-1|3,3',4',5,6,7,8-heptamethoxyflavone

Introduction：Basic information about CAS 1178-24-1|3,3',4',5,6,7,8-heptamethoxyflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 3,3',4',5,6,7,8-heptamethoxyflavone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	3,3',4',5,6,7,8-heptamethoxyflavone
CAS Number	1178-24-1	Molecular Weight	432.421
Density	1.3±0.1 g/cm3	Boiling Point	618.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₄O₉	Melting Point	/
MSDS	/	Flash Point	268.0±31.5 °C

Names

Name	2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxychromen-4-one
Synonym	More Synonyms

3,3',4',5,6,7,8-heptamethoxyflavone BiologicalActivity

Description	3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2). [2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9. [3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813. [4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Description

3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2).

[2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9.

[3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813.

[4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	618.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₄O₉
Molecular Weight	432.421
Flash Point	268.0±31.5 °C
Exact Mass	432.142029
PSA	94.82000
LogP	1.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.576
InChIKey	SSXJHQZOHUYEGD-UHFFFAOYSA-N
SMILES	COc1ccc(-c2oc3c(OC)c(OC)c(OC)c(OC)c3c(=O)c2OC)cc1OC

Safety Information

HS Code	2914509090

Customs

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Synonyms

2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-chromen-4-one

3',4',3,5,6,7,8-heptamethoxyflavone

3-Hptmf

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-

Hepta-3

3,5,6,7,8,3',4'-Heptamethoxyflavone

3,3',4',5,6,7,8-Heptamethoxyflavone

3,5,6,7,8,3’,4’- heptemthoxyflavone

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