Introduction：Basic information about CAS 15266-38-3|Evocarpine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Evocarpine |
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| CAS Number | 15266-38-3 | Molecular Weight | 339.514 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 456.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C23H33NO | Melting Point | 34-38℃ |
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| MSDS | / | Flash Point | 156.1±18.1 °C |
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Names
| Name | (Z)-1-Methyl-2-(tridec-8-en-1-yl)quinolin-4(1H)-one |
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| Synonym | More Synonyms |
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Evocarpine BiologicalActivity
| Description | Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Cumulative application of evocarpine (1-100 μM) inhibits the sustained contraction induced by 60 mM K+ in a concentration-dependent manner[1]. Evocarpine is found to induce apoptotic cell death in promyelocytic leukaemia HL‐60 cells in dose- and time-dependent manners[3]. |
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| References | [1]. J Yamahar, et al. The vasorelaxant effect of evocarpine in isolated aortic strips: mode of action. Eur J Pharmacol. 1988 Oct 11;155(1-2):139-43. [2]. C Hochfellner, et al. Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 2015 Apr;118(4):864-72. [3]. N Y Kim, et al. Cyclic adenosine monophosphate inhibits quinolone alkaloid evocarpine-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 2000 Jul;87(1):1-5. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 456.2±45.0 °C at 760 mmHg |
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| Melting Point | 34-38℃ |
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| Molecular Formula | C23H33NO |
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| Molecular Weight | 339.514 |
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| Flash Point | 156.1±18.1 °C |
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| Exact Mass | 339.256226 |
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| PSA | 22.00000 |
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| LogP | 7.70 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.526 |
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| InChIKey | HWFYWIVOYBPLQU-UHFFFAOYSA-N |
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| SMILES | CCCCC=CCCCCCCCc1cc(=O)c2ccccc2n1C |
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| Storage condition | 2-8C |
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Synonyms
| 4(1H)-Quinolinone, 1-methyl-2-(8-tridecenyl)-, (Z)- |
| 4(1H)-Quinolinone, 1-methyl-2-[(8Z)-8-tridecen-1-yl]- |
| 1-Methyl-2-[(8Z)-8-tridecen-1-yl]-4(1H)-quinolinone |
| evocarpine |
