CAS 1404-19-9|Oligomycin

Introduction：Basic information about CAS 1404-19-9|Oligomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Oligomycin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles9
7. Synonyms

Common Name	Oligomycin
CAS Number	1404-19-9	Molecular Weight	2371.171
Density	1.14 g/cm3	Boiling Point	886.3ºC at 760 mmHg
Molecular Formula	C₁₃₅H₂₂₀O₃₃	Melting Point	84-100ºC
MSDS	ChineseUSA	Flash Point	252ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	Oligomycin
Synonym	More Synonyms

Oligomycin BiologicalActivity

Description	Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis.
Related Catalog	Signaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Membrane Transporter/Ion Channel >>ATP Synthase

Chemical & Physical Properties

Density	1.14 g/cm3
Boiling Point	886.3ºC at 760 mmHg
Melting Point	84-100ºC
Molecular Formula	C₁₃₅H₂₂₀O₃₃
Molecular Weight	2371.171
Flash Point	252ºC
Exact Mass	2369.553711
PSA	536.99000
LogP	17.71190
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.543
Storage condition	−20°C
Water Solubility	Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK3325000

CHEMICAL NAME :: Oligomycin

CAS REGISTRY NUMBER :: 1404-19-9

LAST UPDATED :: 199012

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 15,660,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	24/25
RIDADR	UN 2811
WGK Germany	3
RTECS	RK3325000
Packaging Group	III
Hazard Class	6.1(b)

Articles9

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.

Mol. Endocrinol. 29(1) , 130-9, (2014)

Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 d...

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

Nat. Commun. 6 , 6750, (2015)

During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we...

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.

Sci. Rep. 5 , 16895, (2015)

Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) regulates cha...

Synonyms

Oligomycin From Streptomyces Diastatochromogenes

EINECS 215-767-9

MFCD00065705

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