Introduction：Basic information about CAS 866823-73-6|Biphenylindanone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biphenylindanone A |
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| CAS Number | 866823-73-6 | Molecular Weight | 454.557 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 676.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H30O4 | Melting Point | / |
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| MSDS | USA | Flash Point | 225.8±25.0 °C |
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Names
| Name | 4-[3-[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydroinden-5-yl)oxymethyl]phenyl]benzoic acid |
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| Synonym | More Synonyms |
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Biphenylindanone A BiologicalActivity
| Description | Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| Target | mGluR2 |
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| In Vitro | Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate[1]. |
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| References | [1]. Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 676.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H30O4 |
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| Molecular Weight | 454.557 |
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| Flash Point | 225.8±25.0 °C |
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| Exact Mass | 454.214417 |
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| PSA | 63.60000 |
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| LogP | 8.27 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.627 |
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| InChIKey | KMKBEESNZAPKMP-UHFFFAOYSA-N |
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| SMILES | Cc1c(OCc2cccc(-c3ccc(C(=O)O)cc3)c2)cc2c(c1C)C(=O)C(C1CCCC1)C2 |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| LS-193,571 |
| BINA |
| [1,1'-Biphenyl]-4-carboxylic acid, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]- |
| 3'-{[(2-Cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}-4-biphenylcarboxylic acid |
| cc-230 |
| Biphenylindanone A |
