CAS 20601-85-8|Tetrahydromagnolol
Introduction：Basic information about CAS 20601-85-8|Tetrahydromagnolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tetrahydromagnolol | ||
|---|---|---|---|
| CAS Number | 20601-85-8 | Molecular Weight | 270.366 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 400.5±40.0 °C at 760 mmHg |
| Molecular Formula | C18H22O2 | Melting Point | / |
| MSDS | / | Flash Point | 182.2±21.9 °C |
Names
| Name | 2-(2-hydroxy-5-propylphenyl)-4-propylphenol |
|---|---|
| Synonym | More Synonyms |
Tetrahydromagnolol BiologicalActivity
| Description | Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>GPR55Signaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor |
| Target | CB2:170 nM (EC50) CB2:416 nM (Ki) CB1:9010 nM (EC50) CB1:2260 nM (Ki) GPR55 receptor |
| References | [1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 400.5±40.0 °C at 760 mmHg |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.366 |
| Flash Point | 182.2±21.9 °C |
| Exact Mass | 270.161987 |
| PSA | 40.46000 |
| LogP | 4.95 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.577 |
| InChIKey | OYAQUBKYAKSHOA-UHFFFAOYSA-N |
| SMILES | CCCc1ccc(O)c(-c2cc(CCC)ccc2O)c1 |
Safety Information
| HS Code | 2907299090 |
|---|
Customs
| HS Code | 2907299090 |
|---|---|
| Summary | 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
Synonyms
| MLO |
| [1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl- |
| 2,2'-dihydroxy-5,5'-dipropylbiphenyl |
| 5,5'-propyl-2,2'-dihydroxy-1,1'-biphenyl |
| 5,5'-Dipropyl-2,2'-biphenyldiol |
| 5.5'-Dipropyl-biphenyl-2.2'-diol |
| 5,5'-dipropylbiphenyl-2,2'-diol |
| tetrahydro-magnolol |
| 6,6'-Dihydroxy-3,3'-dipropyl-biphenyl |
