CAS 123562-20-9|Endothelin-2 (human, canine) acetate salt
| Common Name | Endothelin-2 (human, canine) acetate salt | ||
|---|---|---|---|
| CAS Number | 123562-20-9 | Molecular Weight | 2546.92000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C115H160N26O32S4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | h-cys-ser-cys-ser-ser-trp-leu-asp-lys-glu-cys-val-tyr-phe-cys-his-leu-asp-ile-ile-trp-oh |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Endothelin-2, human is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular DiseasePeptides |
| Target | ET-RA, ET-RB[1] |
| In Vitro | At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1]. Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2]. |
| In Vivo | Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1]. |
| Animal Admin | Rats[1] For the assay of pressor activity, male Wistar rats weighing 300-350 g are anesthetized with urethane (1 g/kg i.p.) and pretreated with atropine (0.25 mg/kg i.v.), propranolol (1 mg/kg i.v.), and bunazocine (1 mg/kg i.v.). Additional maintenance doses (one-half of the initial doses) of the autonomic blockades are administered every 3-4 hr. Each animal is given only one bolus of Endothelin-2. 1 nM of Endothelin-2 in 50 μL of buffer is bolus injected from a cannula inserted in the right femoral vein. The blood pressure is recorded from a cannula, which is placed in the right carotid artery and connected to a pressure transducer[1]. |
| References | [1]. Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400. |
Chemical & Physical Properties
| Molecular Formula | C115H160N26O32S4 |
|---|---|
| Molecular Weight | 2546.92000 |
| Exact Mass | 2545.06000 |
| PSA | 1025.62000 |
| LogP | 4.59880 |
| Appearance of Characters | powder | white |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S28-S45-S36-S37 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
Articles9
More Articles| Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells. Neuro. Oncol. 16(12) , 1585-98, (2014) Recent evidence suggests that astrocytes protect cancer cells from chemotherapy by stimulating upregulation of anti-apoptotic genes in those cells. We investigated the possibility that activation of t... | |
| Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation. PLoS ONE 8 , e65486, (2013) There is evidence for a role of ionizing radiation in cardiovascular diseases. The goal of this work was to identify changes in oxidative and nitrative stress pathways and the status of the endothelin... | |
| The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U. S. A. 86 , 2863-2867, (1989) Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endot... |
Synonyms
| Endothelin 2,human |
| MFCD00133306 |
| Endothelin-2,human |
| Endothelin-2, human |
