Introduction：Basic information about CAS 128196-01-0|Escitalopram, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Escitalopram |
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| CAS Number | 128196-01-0 | Molecular Weight | 324.39 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 428.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H21FN2O | Melting Point | / |
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| MSDS | / | Flash Point | 212.8±28.7 °C |
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Names
| Name | escitalopram |
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| Synonym | More Synonyms |
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Escitalopram BiologicalActivity
| Description | Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Serotonin TransporterResearch Areas >>Neurological DiseaseNatural Products >>Others |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21. [2]. Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 428.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H21FN2O |
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| Molecular Weight | 324.39 |
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| Flash Point | 212.8±28.7 °C |
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| PSA | 110.86000 |
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| LogP | 2.51 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.591 |
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| InChIKey | WSEQXVZVJXJVFP-FQEVSTJZSA-N |
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| SMILES | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| MFCD06407826 |
| UNII-4O4S742ANY |
| Escitalopram |
| 5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1S)- |
| (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile |
| Seroplex |
| Citalopram |
| (+)-Citalopram |
| Lexapro |
| (S)-citalopram |
| S(+)-citalopram |
| Cipralex |
| S-(+)-Citalopram |
| (1S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile |
