CAS 75172-81-5|Migalastat hydrochloride

Introduction：Basic information about CAS 75172-81-5|Migalastat hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Migalastat hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	Migalastat hydrochloride
CAS Number	75172-81-5	Molecular Weight	199.63300
Density	/	Boiling Point	382.7ºC at 760 mmHg
Molecular Formula	C₆H₁₄ClNO₄	Melting Point	260ºC
MSDS	USA	Flash Point	185.2ºC

Names

Name	deoxygalactonojirimycin, hydrochloride
Synonym	More Synonyms

Migalastat hydrochloride BiologicalActivity

Description	Migalastat hydrochloride (1-Deoxygalactonojirimycin hydrochloride) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Others
Target	IC50: 0.04 μM (human α-Gal A)[1];Ki: 0.04 μM (human α-Gal A)[1]
In Vitro	Both IC50 and Ki values of migalastat hydrochloride toward human lysosomal a-Gal A are 0.04 μM[1].
In Vivo	Fabry disease is an X-linked recessive disorder caused by the deficient activity of α-galactosidase A. α-Gal A activity in heart, kidney, spleen, and liver is increased dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A with migalastat hydrochloride treatment. The half-life of DGJ is less than 1 day in all major issues and that of the enzyme synthesized during the DGJ treatment period is approximately 4 days[2]. Oral administration of migalastat hydrochloride reduces tissue GL-3 in fabry transgenic mice, and in urine and kidneys of some FD patients. Oral administration of migalastat hydrochloride to transgenic mice reduces elevated lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively, generally equal to or greater than observed for GL-3[3].
Animal Admin	Mice: Migalastat hydrochloride is dissolved in drinking water. Age-matched male homozygous TgM, TgM/KO, and nontransgenic (Non-Tg) C57BL/6 mice are supplied drinking water containing DGJ ad libitum. Body weight is monitored weekly during the DGJ treatment period. Average daily DGJ dosage is estimated based on the consumption of drinking water. Mice fed drinking water containing DGJ at 0.05 mM typically received DGJ at approximately 3 mg/kg body weight/day[2].
References	[1]. Asano N, et al. In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. Eur J Biochem. 2000 Jul;267(13):4179-86. [2]. Ishii S, et al. Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. J Pharmacol Exp Ther. 2009 Mar;328(3):723-31. [3]. Young-Gqamana B, et al. Migalastat HCl reduces globotriaosylsphingosine (lyso-Gb3) in Fabry transgenic mice and in the plasma of Fabry patients. PLoS One. 2013;8(3):e57631.

Chemical & Physical Properties

Boiling Point	382.7ºC at 760 mmHg
Melting Point	260ºC
Molecular Formula	C₆H₁₄ClNO₄
Molecular Weight	199.63300
Flash Point	185.2ºC
Exact Mass	199.06100
PSA	92.95000
InChIKey	ZJIHMALTJRDNQI-OLALXQGDSA-N
SMILES	Cl.OCC1NCC(O)C(O)C1O

Safety Information

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Articles1

Paulsen, H., et al.

Chem. Ber. 113 , 2601, (1980)

Synonyms

(1R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidinium chloride

1,5-dideoxy-1,5-imino-D-glucitol hydrochloride

1-Deoxymannojirimycinehydrochloride

DEOXYMANNONOJIRIMYCIN HCL

(+)-(2R,3R,4R,5S)-2-hydroxymethyl-3,4,5-trihydroxypiperidine hydrochloride

DEOXYMANNOJIRIMYCIN,HYDROCHLORIDE

(+)-1-deoxynojirimycin hydrochloride

1-DEOXYMANNOJIRIMYCIN HCL

DMM

DEOXYMANNOJIRIMYCIN HCL

DMJ,HYDROCHLORIDE

1-DeoxymannojirimycineHCl

Migalastat (hydrochloride)

Recommended......