Introduction：Basic information about CAS 95093-99-5|(R)-(+)-Carvedilol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R)-(+)-Carvedilol |
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| CAS Number | 95093-99-5 | Molecular Weight | 406.47400 |
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| Density | 1.25g/cm3 | Boiling Point | 655.2ºC at 760 mmHg |
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| Molecular Formula | C24H26N2O4 | Melting Point | 114-115ºC |
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| MSDS | / | Flash Point | 350.1ºC |
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Names
| Name | (2R)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol |
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| Synonym | More Synonyms |
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(R)-(+)-Carvedilol BiologicalActivity
| Description | (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | β/α-1 adrenergic receptor[1] |
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| References | [1]. Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. |
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Chemical & Physical Properties
| Density | 1.25g/cm3 |
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| Boiling Point | 655.2ºC at 760 mmHg |
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| Melting Point | 114-115ºC |
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| Molecular Formula | C24H26N2O4 |
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| Molecular Weight | 406.47400 |
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| Flash Point | 350.1ºC |
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| Exact Mass | 406.18900 |
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| PSA | 75.74000 |
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| LogP | 4.12890 |
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| Index of Refraction | 1.657 |
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| InChIKey | OGHNVEJMJSYVRP-QGZVFWFLSA-N |
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| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
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| Storage condition | 2-8°C |
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Synonyms
| (R)-(+)-Carvedilol |
| S-(-)-1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol |
| (S)-carvedilol |
| (+)-Carvedilol |
| Carvedilol Impurity 10 |
