CAS 9000-69-5|Pectin
Introduction：Basic information about CAS 9000-69-5|Pectin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pectin | ||
|---|---|---|---|
| CAS Number | 9000-69-5 | Molecular Weight | 150.130 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 415.5±38.0 °C at 760 mmHg |
| Molecular Formula | C5H10O5 | Melting Point | 6.1ºC |
| MSDS | ChineseUSA | Flash Point | 219.2±23.3 °C |
Names
| Name | pectin |
|---|---|
| Synonym | More Synonyms |
Pectin BiologicalActivity
| Description | Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| Target | Human Endogenous Metabolite |
| In Vitro | Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1]. Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2]. Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2]. Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2]. Pectin exhibits the antibacterial activity via its undissociated acid form[2]. |
| In Vivo | Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1]. |
| References | [1]. Verma AK, et al. Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102. [2]. Ciriminna R, et al. Pectin: A Long-Neglected Broad-Spectrum Antibacterial. ChemMedChem. 2020 Dec 3;15(23):2228-2235. [3]. Wikiera A, et al. Prozdrowotne właściwości pektyn [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. Polish. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 415.5±38.0 °C at 760 mmHg |
| Melting Point | 6.1ºC |
| Molecular Formula | C5H10O5 |
| Molecular Weight | 150.130 |
| Flash Point | 219.2±23.3 °C |
| Exact Mass | 150.052826 |
| PSA | 97.99000 |
| LogP | -2.39 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.544 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble0.02g/10 mL, clear to hazy, colorless to very faintly yellow | It is soluble in water. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),58S,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84368 No. of Facilities: 1645 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 16045 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7456 No. of Facilities: 1936 (estimated) No. of Industries: 9 No. of Occupations: 19 No. of Employees: 54050 (estimated) No. of Female Employees: 46189 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| RTECS | RX4280000 |
| HS Code | 1302200000 |
Customs
| HS Code | 1302200000 |
|---|
Articles75
More Articles| Development of a green binder system for paper products. BMC Biotechnol. 13 , 28, (2013) It is important for industries to find green chemistries for manufacturing their products that have utility, are cost-effective and that protect the environment. The paper industry is no exception. Re... | |
| Dietary pectin-derived acidic oligosaccharides improve the pulmonary bacterial clearance of Pseudomonas aeruginosa lung infection in mice by modulating intestinal microbiota and immunity. J. Infect. Dis. 211(1) , 156-65, (2015) A predominantly T-helper type 2 (Th2) immune response is critical in the prognosis of pulmonary Pseudomonas aeruginosa infection. But the mucosal and systemic immune responses can be influenced by the... | |
| Aegle marmelos fruit pectin for food and pharmaceuticals: Physico-chemical, rheological and functional performance. Carbohydr. Polym. 93(2) , 386-94, (2013) Pectin is used in a number of foods as a gelling agent, thickener, texturizer, emulsifier and stabilizer. Bael fruit, obtained from Aegle marmelos, is a rich source of pectin. Bael fruit pectin (BFP) ... |
Synonyms
| gentisic acid dimethyl ether |
| Dimethylaethergentisinsaeure |
| 6-methoxy-m-anisic acid |
| 2,5-dimethoxy-benzoic acid |
| 2,5-dimethoxylbenzoic acid |
| Benzoic acid,2,5-dimethoxy |
| EINECS 232-553-0 |
| 2,5-Dimethoxy-benzoesaeure |
| Pentose |
| MFCD00081838 |
| 2,5-bis-methoxybenzoic acid |
| GENU Pectin USP-H |
| polygalacturonic acid |
