CAS 8049-97-6|Melanin
| Common Name | Melanin | ||
|---|---|---|---|
| CAS Number | 8049-97-6 | Molecular Weight | 318.28300 |
| Density | 1.65g/cm3 | Boiling Point | 500.5ºC at 760 mmHg |
| Molecular Formula | C18H10N2O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 195.4ºC |
Names
| Name | Melanin |
|---|---|
| Synonym | More Synonyms |
Melanin BiologicalActivity
| Description | Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Melanin contributes to the ability of fungi to survive in harsh environments. In addition, it plays a role in fungal pathogenesis. Melanin is an amorphous polymer that is produced by one of two synthetic pathways. Fungi may synthesize melanin from endogenous substrate via a 1,8-dihydroxynaphthalene (DHN) intermediate. Alternatively, some fungi produce melanin from L-3,4-dihydroxyphenylalanine (L-dopa)[1]. |
| References | [1]. Eisenman HC, et al. Synthesis and assembly of fungal melanin. Appl Microbiol Biotechnol. 2012 Feb;93(3):931-40. |
Chemical & Physical Properties
| Density | 1.65g/cm3 |
|---|---|
| Boiling Point | 500.5ºC at 760 mmHg |
| Molecular Formula | C18H10N2O4 |
| Molecular Weight | 318.28300 |
| Flash Point | 195.4ºC |
| Exact Mass | 318.06400 |
| PSA | 99.86000 |
| LogP | 1.32660 |
| Index of Refraction | 1.771 |
| InChIKey | XUMBMVFBXHLACL-UHFFFAOYSA-N |
| SMILES | Cc1c(=O)c(=O)c2c3c[nH]c4c(C)c(=O)c(=O)c(c5c[nH]c1c52)c43 |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| HS Code | 3203001990 |
Customs
| HS Code | 3203001990 |
|---|
Articles8
More Articles| Testing in mice the hypothesis that melanin is protective in malaria infections. PLoS ONE 7 , e29493, (2012) Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern human... | |
| Identification of quinolines that inhibit melanogenesis by altering tyrosinase family trafficking. Mol. Pharmacol. 74 , 1576-86, (2009) A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship... | |
| Ex vivomodels to evaluate the role of ocular melanin in trans-scleral drug delivery Eur. J. Pharm. Sci. 46(5) , 475-83, (2012) Trans-scleral delivery is nowadays considered as a possible way to deliver drugs to the posterior segment of the eye. Despite the potentiality of this administration route, there is a lack of fundamen... |
Synonyms
| EINECS 232-473-6 |
| MFCD00131581 |
