CAS 40957-99-1|Medioresil

Introduction：Basic information about CAS 40957-99-1|Medioresil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Medioresil BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Medioresil
CAS Number	40957-99-1	Molecular Weight	388.411
Density	1.3±0.1 g/cm3	Boiling Point	575.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₇	Melting Point	/
MSDS	/	Flash Point	302.0±30.1 °C

Names

Name	4-[(1S,3aR,4S,6aR)-4-(4-Hydroxy-3-methoxyphenyl)tetrahydro-1H,3H- furo[3,4-c]furan-1-yl]-2,6-dimethoxyphenol
Synonym	More Synonyms

Medioresil BiologicalActivity

Description	(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalResearch Areas >>Neurological DiseaseSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Ji Hong Hwang, et al. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94(8):1784-93. [2]. Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41.

Description

(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk[1][2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalResearch Areas >>Neurological DiseaseSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Ji Hong Hwang, et al. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94(8):1784-93.

[2]. Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	575.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₇
Molecular Weight	388.411
Flash Point	302.0±30.1 °C
Exact Mass	388.152191
PSA	86.61000
LogP	1.12
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.587
InChIKey	VJOBNGRIBLNUKN-BMHXQBNDSA-N
SMILES	COc1cc(C2OCC3C(c4cc(OC)c(O)c(OC)c4)OCC23)ccc1O

Synonyms

5-methoxypinoresinol

5-methoxyphenylhydrazine hydrochloride

4-[(1S,3aR,4S,6aR)-4-(4-Hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2,6-dimethoxyphenol

Phenol, 2,6-dimethoxy-4-[(1S,3aR,4S,6aR)-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]-

m-methoxyphenylhydrazine hydrochloride

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