Introduction：Basic information about CAS 55497-79-5|Myriceric acid B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Myriceric acid B |
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| CAS Number | 55497-79-5 | Molecular Weight | 634.842 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 752.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C39H54O7 | Melting Point | / |
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| MSDS | / | Flash Point | 227.0±26.4 °C |
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Names
| Name | (3β)-27-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}-3-hydroxy olean-12-en-28-oic acid |
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| Synonym | More Synonyms |
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Myriceric acid B BiologicalActivity
| Description | Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
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| Target | HIV-1:8.3±0.2 μg/mL (IC50, infection of HIV-1 Env pseudovirus) |
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| In Vitro | Myriceric acid B (0-30 μM; 72 h) 对肿瘤细胞有强烈的细胞毒性[1]。 Myriceric acid B 抑制 HIV-1 Env 假病毒感染的 IC50 为 8.3±0.2 mg/L[2]。 Cell Cytotoxicity Assay[1] Cell Line: A549, SK-OV-3, SK-MEL-2 and Bt549 Concentration: 0-30 μM Incubation Time: 72 h Result: Exhibited potent cytotoxicity against all of the tumor cell lines tested, with IC50s of 5.7±0.3, 9.8±0.5, 6.0±0.7 and 5.8±0.4 μM against A549, SK-OV-3, SK-MEL-2 and Bt549, respectively. |
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| References | [1]. Eom HJ, et al. Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chem Biodivers. 2017 Apr;14(4). [2]. Xia C, et al. The anti-HIV-1 entrance activity and mechanism of action of myriceric acid B from Rhoiptelea chiliantha Diels et Hand-Mazz. Chinese Pharmacological Bulletin, 2010: 447-452. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 752.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C39H54O7 |
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| Molecular Weight | 634.842 |
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| Flash Point | 227.0±26.4 °C |
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| Exact Mass | 634.386963 |
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| PSA | 124.29000 |
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| LogP | 9.07 |
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| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
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| Index of Refraction | 1.610 |
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| InChIKey | IZCSLJUDQLFLNO-OUFIAWICSA-N |
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| SMILES | CC1(C)CCC2(C(=O)O)CCC3(COC(=O)C=Cc4ccc(O)c(O)c4)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1 |
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Safety Information
Synonyms
| (3β)-27-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}-3-hydroxyolean-12-en-28-oic acid |
| Myriceron caffeoyl ester |
| Myriceric acid B |
| myriceric acid A |
| Olean-12-en-28-oic acid, 27-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3-hydroxy-, (3β)- |
