CAS 199739-10-1|Paliperidone Palmitate

Introduction：Basic information about CAS 199739-10-1|Paliperidone Palmitate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePaliperidone Palmitate
CAS Number199739-10-1Molecular Weight664.893
Density1.2±0.1 g/cm3Boiling Point736.3±70.0 °C at 760 mmHg
Molecular FormulaC39H57FN4O4Melting Point/
MSDS/Flash Point399.1±35.7 °C

Names

Name[3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
SynonymMore Synonyms

Paliperidone Palmitate BiologicalActivity

DescriptionPaliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia[1].
Related CatalogSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
Target

5-HT2A Receptor

D2 Receptor

References

[1]. Kwon JS, et al. Satisfaction of immediate or delayed switch to paliperidone palmitate in patients unsatisfied with current oral atypical antipsychotics. Int Clin Psychopharmacol. 2015;30(6):320-328.

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point736.3±70.0 °C at 760 mmHg
Molecular FormulaC39H57FN4O4
Molecular Weight664.893
Flash Point399.1±35.7 °C
Exact Mass664.436401
PSA90.46000
LogP9.85
Vapour Pressure0.0±2.4 mmHg at 25°C
Index of Refraction1.590
InChIKeyVOMKSBFLAZZBOW-UHFFFAOYSA-N
SMILESCCCCCCCCCCCCCCCC(=O)OC1CCCn2c1nc(C)c(CCN1CCC(c3noc4cc(F)ccc34)CC1)c2=O
Storage condition-20℃

Synonyms

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido-[1,2-a]pyrimidin-4-one palmitate ester
9-Hydroxyrisperidone palmitate
Xeplion
PALPERIDONE PALMITATE
UNII-R8P8USM8FR
Paliperidone Palmitate
Invega Sustenna
Paliperidone Palmitate [USAN]
3-[2-[4-(6-fluoro-1,2-benzoisoxazol-3-yl)-1-piperidyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one palmitate ester
Hexadecanoic acid, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester
3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate
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