CAS 122021-74-3|Magnesium Lithospermate B

Introduction：Basic information about CAS 122021-74-3|Magnesium Lithospermate B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMagnesium Lithospermate B
CAS Number122021-74-3Molecular Weight740.903
Density/Boiling Point1020.3ºC at 760mmHg
Molecular FormulaC36H28MgO16Melting Point/
MSDS/Flash Point322.1ºC

Names

Namemagnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
SynonymMore Synonyms

Magnesium Lithospermate B BiologicalActivity

DescriptionMagnesium Lithospermate B is a derivative of caffeic acid tetramer and extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration[1][2][3].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease
In VitroMagnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis[2]. Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner[3]. Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons[3].
In VivoMagnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats[1]. Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models[3]. Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats[1] Dosage: 2, 8 mg/kg Administration: P.o. once daily for 16 days Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.
References

[1]. Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31(5):721-728.

[2]. Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33(1): 85-91.

[3]. Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14.

Chemical & Physical Properties

Boiling Point1020.3ºC at 760mmHg
Molecular FormulaC36H28MgO16
Molecular Weight740.903
Flash Point322.1ºC
Exact Mass740.122803
PSA283.70000
LogP4.21090
Vapour Pressure0mmHg at 25°C
InChIKeyANUBYMNVOPVATP-OAZHBLANSA-L
SMILESO=C(C=Cc1ccc(O)c2c1C(C(=O)OC(Cc1ccc(O)c(O)c1)C(=O)[O-])C(c1ccc(O)c(O)c1)O2)OC(Cc1ccc(O)c(O)c1)C(=O)[O-].[Mg+2]

Synonyms

Magnesium 2-({(2E)-3-[3-{[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]-2-propenoyl}oxy)-3-(3,4-dihydroxyphenyl)propanoate
Magnesium lithospermate B
Monomethyl lithospermate B
Magnesium aspartate hydrochloride trihydrate
magnessium lithospermate B
Magnesium lithospermate B,Magnesium Tanshinoate B
Magnesate(1-),(L-aspartato(2-)-N,O(sup 1),O(sup 4))chloro-,hydrogen,(T-4),trihydrate
Magnesium L-aspartate hydrochloride trihydrate
3-Benzofurancarboxylic acid, 4-[(1E)-3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, 3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethyl] ester, magnesium salt (1:1)
(L-Aspartato(2-)-N,O(sup 1),O(sup 4))chloromagnesate(1-) hydrogen (T-4) trihydrate
magnesium hydrogen chloride 2-aminobutanedioate(1:1:1:1)
magnesium-L-aspartate hydrochloride
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