CAS 53179-07-0|Nisoxetine

Introduction：Basic information about CAS 53179-07-0|Nisoxetine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nisoxetine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Nisoxetine
CAS Number	53179-07-0	Molecular Weight	271.35400
Density	1.054g/cm3	Boiling Point	404.8ºC at 760mmHg
Molecular Formula	C₁₇H₂₁NO₂	Melting Point	/
MSDS	/	Flash Point	170.6ºC

Names

Name	3-(2-Methoxyphenoxy)-N-methyl-3-phenyl-1-propanamine
Synonym	More Synonyms

Nisoxetine BiologicalActivity

Description	Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Monoamine Transporter
Target	Kd: 0.76 nM (NET)[1]
In Vitro	Nisoxetine 抑制 [3H]Nisoxetine 与大鼠额叶皮层膜的结合，Ki 为 1.4±0.1 nM[2]。 Nisoxetine 抑制[3H]去甲肾上腺素摄取到大鼠额叶皮质突触体中，Ki 为 2.1±0.3 nM[2]。 Nisoxetine 抑制 Na+ 电流，膜电位为 -70 和 -100 mV 时的 IC50 分别为 1.6 和 28.6 µM[3]。
In Vivo	Nisoxetine (2.2 µM; a single intrathecal injection) shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3]. Nisoxetine (3,10, 30 mg/kg, i.p.) inhibits refeeding response (intake of standard chow) in rats[4]. Animal Model: Sprague-Dawley rats(290-340 g)[3] Dosage: 0.6, 1.2, 1.8, 2.2 µM Administration: A single intrathecal injection Result: Showed ED50s of 0.82, 0.75 and 0.70 µM in blocking motor function, proprioception, and nociception respectively.
References	[1]. Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32. [2]. Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70. [3]. Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7. [4]. Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.

Chemical & Physical Properties

Density	1.054g/cm3
Boiling Point	404.8ºC at 760mmHg
Molecular Formula	C₁₇H₂₁NO₂
Molecular Weight	271.35400
Flash Point	170.6ºC
Exact Mass	271.15700
PSA	30.49000
LogP	3.81570
Index of Refraction	1.547
InChIKey	ITJNARMNRKSWTA-UHFFFAOYSA-N
SMILES	CNCCC(Oc1ccccc1OC)c1ccccc1

Safety Information

HS Code	2922299090

Customs

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

3,5-dicarbomethoxy-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine

Adalat CC

4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyridine

Procardia XL

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine-dicarboxylic acid dimethyl ester

Procardia

Adalat

[125I]-Iodonisoxetine

(R,S)-nisoxetine

[3H]-Nifedipine

Fenihidin

N-methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine

Cordipin

[3H]-Nisoxetine

Fenihidine

N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propylamine

Corinfar

4-(2-nitrophenyl)-3,5-dimethoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine

nifedipine

4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine

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