Introduction：Basic information about CAS 865200-20-0|Giripladib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Giripladib |
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| CAS Number | 865200-20-0 | Molecular Weight | 745.25 |
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| Density | 1.29g/cm3 | Boiling Point | / |
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| Molecular Formula | C41H36ClF3N2O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Giripladib |
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| Synonym | More Synonyms |
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Giripladib BiologicalActivity
| Description | Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Inflammation/Immunology |
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| Target | cPLA2α |
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| References | [1]. Kokotos G, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25;57(18):7523-35. [2]. Liu S, et al. A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties. J Hematol Oncol. 2021 Oct 29;14(1):178. |
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Chemical & Physical Properties
| Density | 1.29g/cm3 |
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| Molecular Formula | C41H36ClF3N2O4S |
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| Molecular Weight | 745.25 |
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| Exact Mass | 744.20400 |
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| PSA | 96.78000 |
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| LogP | 10.95850 |
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| InChIKey | NHHBNHIPCSPSHQ-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccccc3C(F)(F)F)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1 |
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| Storage condition | -20°C |
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Synonyms
| PLA 695 |
| 4-[3-[1-benzhydryl-5-chloro-2-[2-[[2-(trifluoromethyl)phenyl]methylsulfonylamino]ethyl]indol-3-yl]propyl]benzoic acid |
