Introduction：Basic information about CAS 192314-93-5|Iclaprim, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Iclaprim |
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| CAS Number | 192314-93-5 | Molecular Weight | 354.403 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 616.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C19H22N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | 326.8±34.3 °C |
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Names
| Name | iclaprim |
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| Synonym | More Synonyms |
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Iclaprim BiologicalActivity
| Description | Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 mg/mL. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| Target | Dihydrofolate[1] |
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| References | [1]. Schneider P, et al. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4217-21. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 616.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C19H22N4O3 |
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| Molecular Weight | 354.403 |
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| Flash Point | 326.8±34.3 °C |
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| Exact Mass | 354.169189 |
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| PSA | 105.51000 |
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| LogP | 2.20 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.666 |
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| InChIKey | HWJPWWYTGBZDEG-UHFFFAOYSA-N |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)c2c(c1OC)OC(C1CC1)C=C2 |
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| Storage condition | 2-8℃ |
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Synonyms
| Iclaprim |
| 2,4-Pyrimidinediamine, 5-[(2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl)methyl]- |
| 5-[(2-cyclopropyl-7,8-dimethoxy-2h-chromen-5-yl)methyl]pyrimidine-2,4-diamine |
| 5-[(2-Cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]-2,4-pyrimidinediamine |
