CAS 352513-83-8|Semapimod
Introduction：Basic information about CAS 352513-83-8|Semapimod, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Semapimod | ||
|---|---|---|---|
| CAS Number | 352513-83-8 | Molecular Weight | 744.90 |
| Density | 1.39 | Boiling Point | / |
| Molecular Formula | C34H52N18O2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | N,N'-bis[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide |
|---|---|
| Synonym | More Synonyms |
Semapimod BiologicalActivity
| Description | Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
| Target | CD40 IL-1β IL-6 p38 MAPK |
| References | [1]. Nishimatsu H, et al. Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats. Hypertens Res. 2008;31(4):737‐743. [2]. Wehner S, Set al. Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology. 2009;136(2):619‐629. [3]. Wang J, et al. Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol. 2016;196(12):5130‐5137. [4]. Miller IS, et al. Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia. PLoS One. 2014 May 9;9(5):e95885. |
Chemical & Physical Properties
| Density | 1.39 |
|---|---|
| Molecular Formula | C34H52N18O2 |
| Molecular Weight | 744.90 |
| Exact Mass | 744.45200 |
| PSA | 355.24000 |
| LogP | 7.12260 |
| Index of Refraction | 1.677 |
| InChIKey | PWDYHMBTPGXCSN-VCBMUGGBSA-N |
| SMILES | CC(=NN=C(N)N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(C(C)=NN=C(N)N)cc(C(C)=NN=C(N)N)c2)cc(C(C)=NN=C(N)N)c1 |
Synonyms
| AXD455 |
| UNII-9SGW2H1K8P |
| Semapimod |
| CNI-1493 |
