Introduction：Basic information about CAS 834153-87-6|elagolix, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | elagolix |
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| CAS Number | 834153-87-6 | Molecular Weight | 631.590 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 728.6±70.0 °C at 760 mmHg |
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| Molecular Formula | C32H30F5N3O5 | Melting Point | / |
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| MSDS | / | Flash Point | 394.5±35.7 °C |
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Names
| Name | Elagolix |
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| Synonym | More Synonyms |
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elagolix BiologicalActivity
| Description | Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).Target: GnRHin vitro: Elagolix is a short-acting, nonpeptide, GnRH antagonist, administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses. Elagolix is regarded as the frontrunner of a new class of GnRH inhibitors that have been denoted as second-generation, due to their non-peptide nature and oral bioavailability. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorResearch Areas >>Cancer |
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| References | [1]. Carr B, et al. Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density. Reprod Sci. 2014 Nov;21(11):1341-1351. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 728.6±70.0 °C at 760 mmHg |
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| Molecular Formula | C32H30F5N3O5 |
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| Molecular Weight | 631.590 |
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| Flash Point | 394.5±35.7 °C |
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| Exact Mass | 631.210571 |
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| PSA | 102.56000 |
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| LogP | 7.20 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.567 |
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| InChIKey | HEAUOKZIVMZVQL-VWLOTQADSA-N |
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| SMILES | COc1cccc(-c2c(C)n(Cc3c(F)cccc3C(F)(F)F)c(=O)n(CC(NCCCC(=O)O)c3ccccc3)c2=O)c1F |
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| Storage condition | 2-8℃ |
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Synonyms
| 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid |
| 4-({(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]-1-phenylethyl}amino)butanoic acid |
| Butanoic acid, 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]- |
| Elagolix |
