Introduction：Basic information about CAS 355129-15-6|eprotirome, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | eprotirome |
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| CAS Number | 355129-15-6 | Molecular Weight | 487.139 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | 596.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H17Br2NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 314.4±30.1 °C |
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Names
| Name | 3-[3,5-dibromo-4-(4-hydroxy-3-propan-2-ylphenoxy)anilino]-3-oxopropanoic acid |
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| Synonym | More Synonyms |
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eprotirome BiologicalActivity
| Description | Eprotirome is a liver-selective thyroid hormone receptor agonist. |
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| Related Catalog | Signaling Pathways >>Others >>Thyroid Hormone ReceptorResearch Areas >>EndocrinologyResearch Areas >>Metabolic Disease |
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| Target | Thyroid hormone receptor[1] |
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| In Vivo | Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice[1]. |
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| Animal Admin | Twelve-week old male ob/ob mice are used in this study. A catheter is implanted into the right internal jugular vein before the hyperinsulinemic-euglycemic clamp. After recovery, mice are administered Eprotirome (0.3 mg/kg) via intraperitoneal injection for 10 days. On the day of the clamp experiment, conscious, overnight-fasted mice receive a primed (10 μCi) and constant rate intravenous infusion (0.1 μCi /min) of [3-3H] glucose to measure basal glucose turnover. After 60 to 75 minutes of labeled glucose infusion, the hyperinsulinemic-euglycemic clamp is performed with continuous infusion of insulin (12 mU/kg/min) and variable infusion of 25% glucose to maintain euglycemia (~120 mg/dL). Blood samples are collected by tail bleeding (approximately every 10 min) to measure blood glucose concentrations[1]. |
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| References | [1]. Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10(4):e0122987. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 596.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H17Br2NO5 |
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| Molecular Weight | 487.139 |
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| Flash Point | 314.4±30.1 °C |
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| Exact Mass | 484.947327 |
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| PSA | 95.86000 |
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| LogP | 5.62 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.655 |
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| InChIKey | VPCSYAVXDAUHLT-UHFFFAOYSA-N |
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| SMILES | CC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(=O)O)cc2Br)ccc1O |
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| Storage condition | 2-8℃ |
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Synonyms
| eprotirome |
| Propanoic acid, 3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)phenoxy]phenyl]amino]-3-oxo- |
| UNII-958AQ7B6R1 |
| 3-((3,5-dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid |
| 3-{[3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]amino}-3-oxopropanoic acid |
| KB2115 |
