Introduction：Basic information about CAS 519055-62-0|Tasisulam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tasisulam |
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| CAS Number | 519055-62-0 | Molecular Weight | 415.110 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C11H6BrCl2NO3S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide |
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| Synonym | More Synonyms |
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Tasisulam BiologicalActivity
| Description | Tasisulam is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam induces apoptosis via the intrinsic pathway[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Tasisulam (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s are 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models. |
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| References | [1]. Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10(11):2168-78. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Molecular Formula | C11H6BrCl2NO3S2 |
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| Molecular Weight | 415.110 |
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| Exact Mass | 412.834930 |
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| PSA | 99.86000 |
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| LogP | 3.94 |
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| Index of Refraction | 1.657 |
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| InChIKey | WWONFUQGBVOKOF-UHFFFAOYSA-N |
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| SMILES | O=C(NS(=O)(=O)c1ccc(Br)s1)c1ccc(Cl)cc1Cl |
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| Storage condition | -20℃ |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide |
| Benzamide, N-[(5-bromo-2-thienyl)sulfonyl]-2,4-dichloro- |
| 5-Bromo-N-(2,4-dichlorobenzoyl)-2-thiophenesulfonamide |
| Tasisulam |
| cc-591 |
| UNII-1YC4W9MSLJ |
| T5SJ BSWMVR BG DG&& EE |
| LY573636 |
