Introduction：Basic information about CAS 1571-30-8|8-Hydroxyquinoline-2-Carboxylic Acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 8-Hydroxyquinoline-2-Carboxylic Acid |
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| CAS Number | 1571-30-8 | Molecular Weight | 189.167 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 426.7±30.0 °C at 760 mmHg |
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| Molecular Formula | C10H7NO3 | Melting Point | 213-214 °C |
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| MSDS | ChineseUSA | Flash Point | 211.9±24.6 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 8-hydroxyquinoline-2-carboxylic acid |
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| Synonym | More Synonyms |
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8-Hydroxyquinoline-2-Carboxylic Acid BiologicalActivity
| Description | BAY32-5915 is a potent IKKα inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation[1]. |
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| Related Catalog | Signaling Pathways >>NF-κB >>IKKResearch Areas >>Cancer |
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| Target | IKK-α:60 nM (IC50) |
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| In Vitro | BAY32-5915 (50-200 μM) has no significant inhibitory effect on NF-κB activity in melanoma cells[1]. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 426.7±30.0 °C at 760 mmHg |
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| Melting Point | 213-214 °C |
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| Molecular Formula | C10H7NO3 |
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| Molecular Weight | 189.167 |
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| Flash Point | 211.9±24.6 °C |
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| Exact Mass | 189.042587 |
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| PSA | 70.42000 |
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| LogP | 1.96 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.730 |
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| InChIKey | UHBIKXOBLZWFKM-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccc2cccc(O)c2n1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UZ9450000
- CHEMICAL NAME :
- Quinaldic acid, 8-hydroxy-
- CAS REGISTRY NUMBER :
- 1571-30-8
- BEILSTEIN REFERENCE NO. :
- 0146082
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H7-N-O3
- MOLECULAR WEIGHT :
- 189.18
- WISWESSER LINE NOTATION :
- T66 BNJ CVQ JQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
- REFERENCE :
- ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 108,924,1963 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | UZ9450000 |
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| HS Code | 2933499090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 8-hydroxyquinoline-2-carboxylic acid |
| 8-Hydroxy-2-quinolinecarboxylic acid |
| 2-Quinolinecarboxylic acid, 8-hydroxy- |
| MFCD00168972 |
| Quinaldic acid, 8-hydroxy- |
| 8-Hydroxyquinaldic acid |
