CAS 73604-30-5|(-)-Bicuculline methobromide

Introduction：Basic information about CAS 73604-30-5|(-)-Bicuculline methobromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Bicuculline methobromide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(-)-Bicuculline methobromide
CAS Number	73604-30-5	Molecular Weight	462.29100
Density	/	Boiling Point	/
Molecular Formula	C₂₁H₂₀BrNO₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	6-(6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl)-6H-furo[3,4-g][1,3]benzodioxol-8-one,bromide
Synonym	More Synonyms

(-)-Bicuculline methobromide BiologicalActivity

Description	(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
Target	GABAA[1]
In Vivo	(-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2]. Animal Model: Rat L5-SNL model[2] Dosage: 0.6 nmol/rat Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) Result: Attenuated the antiallodynic effect of Neurotropin.
References	[1]. Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70. [2]. Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9.

Chemical & Physical Properties

Molecular Formula	C₂₁H₂₀BrNO₆
Molecular Weight	462.29100
Exact Mass	461.04700
PSA	63.22000
InChIKey	BWXCECYGGMGBHD-UHFFFAOYSA-M
SMILES	C[N+]1(C)CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3.[Br-]

Safety Information

Safety Phrases	S24/25
RIDADR	UN 1544 6.1/PG 2
Packaging Group	III
Hazard Class	6.1(b)

Synonyms

Guvacine hydrochloride

MFCD00055149

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