CAS 532-65-0|ar-Turmerone

Introduction：Basic information about CAS 532-65-0|ar-Turmerone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ar-Turmerone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles21
7. Synonyms

Common Name	ar-Turmerone
CAS Number	532-65-0	Molecular Weight	216.31900
Density	/	Boiling Point	326℃
Molecular Formula	C₁₅H₂₀O	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	(+)-(S)-ar-turmerone
Synonym	More Synonyms

ar-Turmerone BiologicalActivity

Description	ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-turmerone ((+)-ar-Turmerone) activates apoptotic protein in human lymphoma U937 cells[3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders[4][5].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology
References	[1]. Liju VB, et al. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J Pharmacol. 2011 Sep;43(5):526-31. [2]. Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2011-20. [3]. Lee Y, et al. Activation of apoptotic protein in U937 cells by a component of turmeric oil. BMB Rep. 2009 Feb 28;42(2):96-100. [4]. Yonggang T, et al. Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum Vaccin Immunother. 2012 Oct;8(10):1416-24. [5]. Hucklenbroich J, et al. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res Ther. 2014 Sep 26;5(4):100.

Description

ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-turmerone ((+)-ar-Turmerone) activates apoptotic protein in human lymphoma U937 cells[3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders[4][5].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology

References

[1]. Liju VB, et al. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J Pharmacol. 2011 Sep;43(5):526-31.

[2]. Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2011-20.

[3]. Lee Y, et al. Activation of apoptotic protein in U937 cells by a component of turmeric oil. BMB Rep. 2009 Feb 28;42(2):96-100.

[4]. Yonggang T, et al. Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum Vaccin Immunother. 2012 Oct;8(10):1416-24.

[5]. Hucklenbroich J, et al. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res Ther. 2014 Sep 26;5(4):100.

Chemical & Physical Properties

Boiling Point	326℃
Molecular Formula	C₁₅H₂₀O
Molecular Weight	216.31900
Exact Mass	216.15100
PSA	17.07000
LogP	4.02390
InChIKey	NAAJVHHFAXWBOK-ZDUSSCGKSA-N
SMILES	CC(C)=CC(=O)CC(C)c1ccc(C)cc1

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H317-H319-H411
Precautionary Statements	P273-P280-P305 + P351 + P338
Hazard Codes	Xi,N
Risk Phrases	36-43-51/53
Safety Phrases	36/37-61
RIDADR	UN 3082 9 / PGIII
HS Code	2914399090

Customs

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles21

Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.

Int. J. Food Sci. Nutr. 63(7) , 832-4, (2012)

Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than...

Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line.

Int. J. Mol. Med. 9(5) , 481-4, (2002)

We have investigated the effects of ar-turmerone isolated from turmeric (Curcuma longa L) on DNA of human leukemia cell lines, Molt 4B, HL-60 and stomach cancer KATO III cells. It was found that selec...

Induction of apoptosis by ar-turmerone on various cell lines.

Int. J. Mol. Med. 14(2) , 253-6, (2004)

This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cy...

Synonyms

Tumerone

(+)-ar-Turmerone

(S)-AR-TURMERONE

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