CAS 148849-67-6|Ivabradine hydrochloride
Introduction：Basic information about CAS 148849-67-6|Ivabradine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ivabradine hydrochloride | ||
|---|---|---|---|
| CAS Number | 148849-67-6 | Molecular Weight | 505.046 |
| Density | / | Boiling Point | 626.9ºC at 760mmHg |
| Molecular Formula | C27H37ClN2O5 | Melting Point | 193-196?C |
| MSDS | ChineseUSA | Flash Point | 332.9ºC |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | ivabradine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Ivabradine hydrochloride BiologicalActivity
| Description | Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Cardiovascular Disease |
| In Vivo | Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2]. |
| References | [1]. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7. [2]. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Res Cardiol, 2011. 106(6): p. 1147-58. |
Chemical & Physical Properties
| Boiling Point | 626.9ºC at 760mmHg |
|---|---|
| Melting Point | 193-196?C |
| Molecular Formula | C27H37ClN2O5 |
| Molecular Weight | 505.046 |
| Flash Point | 332.9ºC |
| Exact Mass | 504.239105 |
| PSA | 60.47000 |
| LogP | 4.04990 |
| Vapour Pressure | 1.24E-15mmHg at 25°C |
| InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| SMILES | COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CC1Cc3cc(OC)c(OC)cc31)CC2.Cl |
| Storage condition | -20°C Freezer |
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| Hazard Codes | N |
| Risk Phrases | 50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
Articles1
More Articles| Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs. Cell Physiol. Biochem. 38 , 646-58, (2016) Heart rate variability (HRV) refers to the fluctuation of the time interval between consecutive heartbeats in humans. It has recently been discovered that cardiomyocytes derived from human embryonic a... |
Synonyms
| Ivabradine hydrochloride |
| AMG 998 |
| Coralan |
| Procoralan |
| Corlentor |
| 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride |
| ivabradine monohydrochloride |
| 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride |
| Ivabradine hcl |
| 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1) |
| MFCD00929899 |
| 3-{3-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride (1:1) |
| UNII-TP19837BZK |
| Corlanor |
