CAS 8000-10-0|Sodium theophylline glycinate
Introduction：Basic information about CAS 8000-10-0|Sodium theophylline glycinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium theophylline glycinate | ||
|---|---|---|---|
| CAS Number | 8000-10-0 | Molecular Weight | 277.21200 |
| Density | 1.465 g/cm3 | Boiling Point | 454.1ºC at 760 mmHg |
| Molecular Formula | C9H12N5NaO4 | Melting Point | 272 - 274ºC |
| MSDS | / | Flash Point | 228.4ºC |
Names
| Name | Sodium theophylline glycinate |
|---|---|
| Synonym | More Synonyms |
Sodium theophylline glycinate BiologicalActivity
| Description | Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>Cell Cycle/DNA Damage >>HDACSignaling Pathways >>GPCR/G Protein >>Adenosine ReceptorSignaling Pathways >>Epigenetics >>HDAC |
| In Vitro | Theophylline sodium glycinate (1-1000 µM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries[1]. Theophylline sodium glycinate (10 µg/mL; 24 h) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2 in eosinophils[2]. Theophylline sodium glycinate (0-500 µM; 2 h) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner[3]. Theophylline sodium glycinate (0-1000 µM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression[4]. Western Blot Analysis[3] Cell Line: A549 cells Concentration: 0, 20, 100 and 500 µM Incubation Time: 2 hours Result: Decreased the expression of NF-κB p65 and I-κBα degradation in a dose-dependent manner. |
| In Vivo | Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice[1]. Animal Model: Male Swiss mice[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection; daily; for 9 days Result: Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
| References | [1]. Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. [2]. Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5. [3]. Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. [4]. Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. |
Chemical & Physical Properties
| Density | 1.465 g/cm3 |
|---|---|
| Boiling Point | 454.1ºC at 760 mmHg |
| Melting Point | 272 - 274ºC |
| Molecular Formula | C9H12N5NaO4 |
| Molecular Weight | 277.21200 |
| Flash Point | 228.4ºC |
| Exact Mass | 277.07900 |
| PSA | 138.83000 |
| InChIKey | AIJQWRAOMFRHTQ-UHFFFAOYSA-M |
| SMILES | Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCC(=O)[O-].[Na+] |
Synonyms
| Sodium 2-aminoacetate 1,3-dimethyl-7H-purine-2,6-dione |
