CAS 3513-03-9|blasticidin s hydrochloride
| Common Name | blasticidin s hydrochloride | ||
|---|---|---|---|
| CAS Number | 3513-03-9 | Molecular Weight | 458.90 |
| Density | / | Boiling Point | 772.1ºC at 760 mmHg |
| Molecular Formula | C17H27ClN8O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 420.8ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | (2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride |
|---|---|
| Synonym | More Synonyms |
blasticidin s hydrochloride BiologicalActivity
| Description | Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Blasticidin S (BlaS) is a broad spectrum antibiotic and inhibits cell growth in prokaryotes, fungi, plants, and mammalian cells[1]. |
| References | [1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398. |
Chemical & Physical Properties
| Boiling Point | 772.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C17H27ClN8O5 |
| Molecular Weight | 458.90 |
| Flash Point | 420.8ºC |
| Exact Mass | 458.17900 |
| PSA | 215.67000 |
| LogP | 1.05570 |
| InChIKey | YQXYQOXRCNEATG-UHFFFAOYSA-N |
| SMILES | CN(CCC(N)CC(=O)NC1C=CC(n2ccc(N)nc2=O)OC1C(=O)O)C(=N)N.Cl |
| Storage condition | −20°C |
| Water Solubility | Soluble in water. Insoluble in organic solvents. |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R28 |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
Articles5
More Articles| A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage. J. Inorg. Biochem. 127 , 73-8, (2013) Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. ... | |
| Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome. Proc. Natl. Acad. Sci. U. S. A. 110(30) , 12283-8, (2013) The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and... | |
| Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006) Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and rel... |
Synonyms
| MFCD02091640 |
| Blasticidine S hydrochloride |
| BlasticidinS,monohydrochloride (8CI) |
| Blasticidin S hydrochloride |
