Introduction：Basic information about CAS 57576-44-0|Aclarubicin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aclarubicin |
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| CAS Number | 57576-44-0 | Molecular Weight | 811.86800 |
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| Density | 1.42 g/cm3 | Boiling Point | 897.7ºC at 760 mmHg |
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| Molecular Formula | C42H53NO15 | Melting Point | 151-153ºC |
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| MSDS | / | Flash Point | 496.7ºC |
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Names
| Name | aclacinomycin A |
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| Synonym | More Synonyms |
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Aclarubicin BiologicalActivity
| Description | Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>TopoisomeraseSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Metabolic Enzyme/Protease >>Proteasome |
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| Target | Topoisomerase I Topoisomerase II |
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| In Vitro | Aclacinomycin A (0-120 μM, 30 min) inhibits the ubiquitin-ATP-dependent proteolytic activity of rabbit reticulocytes in a dose-dependent manner, with an IC50 of 52 μM. But it does not inhibit the ubiquitination[1]. Aclacinomycin A inhibits ubiquitin-ATP-dependent proteolysis after the conjugation of ubiquitin to proteins[1]. Aclacinomycin A (0-2.4 μM, 3 h) inhibits the topo II catalytic activity[2]. Aclacinomycin A (0-1.8 μM, 3 h) has negative effect on the proliferative rate of V79 and irs-2 cells[2]. Aclacinomycin A emits fluorescence and that human-cervical cancer HeLa cells exposed to Aclacinomycin A exhibits bright fluorescence signals in the cytoplasm when fluorescence microscopy was performed using the red filter (excitation 530-550 nm/emission 575 nm)[3]. Cell Viability Assay[2] Cell Line: V79 and irs-2 cells Concentration: 0, 0.006, 0.12, 1.2, and 2.4 μM Incubation Time: 3 h Result: Inhibited the topo II catalytic activity in a dose-dependent manner. The loss of topo II catalytic activity in ACLA-treated cells was in all cases significant compared with non-treated cells. Cell Proliferation Assay[2] Cell Line: V79 and irs-2 cells Concentration: 0, 0.12, 0.25, 0.37, 0.6, 1.2, 1.8 μM Incubation Time: 3 h Result: Showed a dose-dependent negative effect on the proliferative rate of V79 and irs-2 cells, but the reduction in surviving colonies was higher in the radiosensitive irs-2 cells for most of the ACLA doses tested. |
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| In Vivo | Aclacinomycin A (0.75-6 mg/kg, IP, daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model[4]. Aclacinomycin A (0.6-20 mg/kg, Orally, daily) exhibits an antitumor effect on leukemia L-1210[4]. Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD50 (76.5 mg/kg) is about twice the iv LD50 (35.6 mg/kg) in mice[4]. Animal Model: DBA/2, CDF1 (BALB/c×DBA/2) mice with Leukemia P-388 (90-110 g)[4]. Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg Administration: Intraperitoneal administration daily for 10 days starting 3 hr after transplantation. Result: Inhibited tumor growth. Animal Model: CDF1 mouse with Leukemia L-1210[4] Dosage: 0.6 mg/kg, 1.25 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg Administration: Orally, daily for days 1-9 Result: Exhibited an antitumor effect on leukemia L-1210. |
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Chemical & Physical Properties
| Density | 1.42 g/cm3 |
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| Boiling Point | 897.7ºC at 760 mmHg |
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| Melting Point | 151-153ºC |
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| Molecular Formula | C42H53NO15 |
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| Molecular Weight | 811.86800 |
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| Flash Point | 496.7ºC |
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| Exact Mass | 811.34200 |
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| PSA | 217.05000 |
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| LogP | 3.15770 |
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| Index of Refraction | 1.629 |
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| InChIKey | USZYSDMBJDPRIF-JEZAGOLQSA-N |
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| SMILES | CCC1(O)CC(OC2CC(N(C)C)C(OC3CC(O)C(OC4CCC(=O)C(C)O4)C(C)O3)C(C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)C1C(=O)OC |
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Safety Information
| Hazard Codes | T |
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| Risk Phrases | R25 |
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| Safety Phrases | S36/37/39-S45 |
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| RIDADR | 3249 |
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| RTECS | QI9279300 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| aclacur |
| ACLARUBLCIN |
| Aclacin |
| Jaclacin |
| ACM |
| Aclarubicin |
| Aelacinon |
| EINECS 260-824-3 |
| MFCD00866250 |
| ma144-a1 |
| Aclaplastin |
