CAS 112809-51-5|Letrozole
| Common Name | Letrozole | ||
|---|---|---|---|
| CAS Number | 112809-51-5 | Molecular Weight | 263.337 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 472.0±55.0 °C at 760 mmHg |
| Molecular Formula | C17H11N5 | Melting Point | 181-183ºC |
| MSDS | ChineseUSA | Flash Point | 214.2±24.5 °C |
Names
| Name | Letrozole |
|---|---|
| Synonym | More Synonyms |
Letrozole BiologicalActivity
| Description | Letrozole is an aromatase inhibitor with an IC50 of 1-13 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>AromataseSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cancer |
| References | [1]. Haynes, B.P., et al., The pharmacology of letrozole. J Steroid Biochem Mol Biol, 2003. 87(1): p. 35-45. [2]. Bhatnagar, A.S., et al., Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol, 1990. 37(6): p. 1021-7. [3]. Dellapasqua, S. and M. Colleoni, Letrozole. Expert Opin Drug Metab Toxicol, 2010. 6(2): p. 251-9. [4]. Lee, K., et al., An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells. Int J Cancer, 1995. 62(3): p. 297-302. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 472.0±55.0 °C at 760 mmHg |
| Melting Point | 181-183ºC |
| Molecular Formula | C17H11N5 |
| Molecular Weight | 263.337 |
| Flash Point | 214.2±24.5 °C |
| Exact Mass | 263.142242 |
| PSA | 78.29000 |
| LogP | 3.70 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.615 |
| InChIKey | HPJKCIUCZWXJDR-UHFFFAOYSA-N |
| SMILES | N#Cc1ccc(C(c2ccc(C#N)cc2)n2cncn2)cc1 |
| Storage condition | -20°C Freezer |
Safety Information
| Hazard Codes | Xi: Irritant;C: Corrosive; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | DI4957000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles104
More Articles| Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis 36(1) , 122-32, (2015) Response to breast cancer chemoprevention can depend upon host genetic makeup and initiating events leading up to preneoplasia. Increased expression of aromatase and estrogen receptor (ER) is found in... | |
| Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice. Mol. Cell. Biol. 35 , 3244-53, (2015) CELF1 is a multifunctional RNA-binding protein that controls several aspects of RNA fate. The targeted disruption of the Celf1 gene in mice causes male infertility due to impaired spermiogenesis, the ... | |
| Aromatase (Cyp19a1b) in the pituitary is dynamically involved in the upregulation of lhb but not fshb in the vitellogenic female ricefield eel Monopterus albus. Endocrinology 155(11) , 4531-41, (2014) Aromatase, encoded by Cyp19a1, is expressed in the pituitary of vertebrates; however, its physiological relevance remains poorly defined. In teleosts, the duplicated cyp19a1b is preferentially express... |
Synonyms
| 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis(benzonitrile) |
| UNII-7LKK855W8I |
| Letrozol |
| Letoval |
| 5-[Bis(4-methylphenyl)methyl]-1H-1,2,4-triazole |
| 1H-1,2,4-Triazole, 5-[bis(4-methylphenyl)methyl]- |
| 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile |
| Femera |
| MFCD00866241 |
| [14C]-Letrozole |
| 4,4'-((1H-1,2,4-Triazol-1-yl)methylene)dibenzonitrile |
| 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile |
| Femara |
| Letrozole |
