CAS 15489-90-4|Hematin
| Common Name | Hematin | ||
|---|---|---|---|
| CAS Number | 15489-90-4 | Molecular Weight | 633.495 |
| Density | / | Boiling Point | 1128.5ºC at 760 mmHg |
| Molecular Formula | C34H33FeN4O5 | Melting Point | 180ºC |
| MSDS | USA | Flash Point | 636.3ºC |
Names
| Name | hematin |
|---|---|
| Synonym | More Synonyms |
Hematin BiologicalActivity
| Description | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin[2]. Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml[2]. Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)[2]. Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin[2]. |
| In Vivo | Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g)[4]. |
| References | [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57. [2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369. [3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43. [4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238. [5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4. |
Chemical & Physical Properties
| Boiling Point | 1128.5ºC at 760 mmHg |
|---|---|
| Melting Point | 180ºC |
| Molecular Formula | C34H33FeN4O5 |
| Molecular Weight | 633.495 |
| Flash Point | 636.3ºC |
| Exact Mass | 633.180054 |
| PSA | 129.41000 |
| LogP | 3.43290 |
| Vapour Pressure | 0mmHg at 25°C |
| InChIKey | CODDGSIFXYHHJO-UHFFFAOYSA-L |
| SMILES | C=CC1=C(C)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C)c5C=C)C(C)=C4CCC(=O)O)c(CCC(=O)O)c3C.O.[Fe+2] |
| Storage condition | 2~8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 40 mg/kg/30D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 101,877,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,329,1978
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
Articles33
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Synonyms
| Hydroxy[dihydrogen Protoporphyrin IX-ato(2-)]iron |
| ferriprotoporphyrin IX hydroxide |
| [Dihydrogen 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]hydroxyiron |
| ferriporphyrin hydroxide |
| heme |
| BOVINE HEMIN |
| ferriheme hydroxide |
| Hydroxy[3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]iron |
| ferrihemate |
| Hematin porcine |
| Hematin |
| Iron, [8,13-diethenyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]hydroxy- |
| ferriprotoporphyrin IX |
| haem |
| ferriprotoporphyrin basic |
| iron protoporphyrin IX |
| MFCD00011615 |
| HAEMATIN |
| HO-Fe(III)(protoporphyrin) |
| hydroxyhemin |
| phenodin |
| ferriheme |
| (SP-5-13)-[7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]oxyferrate(2-) Dihydrogen |
| EINECS 239-518-9 |
