CAS 124753-97-5|N-(hexanoyl)sphing-4-enine
| Common Name | N-(hexanoyl)sphing-4-enine | ||
|---|---|---|---|
| CAS Number | 124753-97-5 | Molecular Weight | 397.63 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 574.7±50.0 °C at 760 mmHg |
| Molecular Formula | C24H47NO3 | Melting Point | 76-77ºC |
| MSDS | ChineseUSA | Flash Point | 301.4±30.1 °C |
Names
| Name | 6-Hexanoyl-D-erythro-sphingosine |
|---|---|
| Synonym | More Synonyms |
N-(hexanoyl)sphing-4-enine BiologicalActivity
| Description | C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| References | [1]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117. [2]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298. |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 574.7±50.0 °C at 760 mmHg |
| Melting Point | 76-77ºC |
| Molecular Formula | C24H47NO3 |
| Molecular Weight | 397.63 |
| Flash Point | 301.4±30.1 °C |
| Exact Mass | 397.355591 |
| PSA | 69.56000 |
| LogP | 8.02 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.483 |
| InChIKey | NPRJSFWNFTXXQC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCC=CC(O)C(CO)NC(=O)CCCCC |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
Articles17
More Articles| Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition. Am. J. Physiol. Cell Physiol. 309 , C239-50, (2015) Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-indu... | |
| Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part. Fibre Toxicol. 9 , 48, (2012) Particulate air pollution in lung epithelial cells induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions. The activation of the epidermal growth factor receptor (E... | |
| Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J. Exp. Clin. Cancer Res 34 , 94, (2015) Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficie... |
Synonyms
| N-Hexanoyl-D-sphingosine |
| N-hexanoyl-D-erythro-sphingosine |
| C6 ceramide Caproyl ceramide N-Caproyl-D-sphingosine |
| N-(hexanoyl)sphing-4-enine |
| N-(hexanoyl)-sphing-4-enine |
| Hexanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]- |
| MFCD00870174 |
| N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]hexanamide |
