CAS 548-19-6|ISOGINKGETIN

Introduction：Basic information about CAS 548-19-6|ISOGINKGETIN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ISOGINKGETIN BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	ISOGINKGETIN
CAS Number	548-19-6	Molecular Weight	566.511
Density	1.5±0.1 g/cm3	Boiling Point	843.6±65.0 °C at 760 mmHg
Molecular Formula	C₃₂H₂₂O₁₀	Melting Point	355ºC
MSDS	/	Flash Point	280.2±27.8 °C

Names

Name	isoginkgetin
Synonym	More Synonyms

ISOGINKGETIN BiologicalActivity

Description	Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.target : MMP-9 [1], Pre-mRNA Splicing [2]IC 50: 30 u M (Pre-mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells. isoginkgetin inhibit activities of both Akt and NF-κB. Isoginkgetin markedly decrease MMP-9 expression and invasion through inhibition of this pathway. [1] Splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. [2] Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. [3]
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>MMPResearch Areas >>CancerNatural Products >>Flavonoids
References	[1]. Yoon SO et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75. [2]. O'Brien K et al. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28;283(48):33147-54. [3]. Liu G et al. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.J Endocrinol. 2007 Sep;194(3):569-78.

Description

Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.target : MMP-9 [1], Pre-mRNA Splicing [2]IC 50: 30 u M (Pre-mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells. isoginkgetin inhibit activities of both Akt and NF-κB. Isoginkgetin markedly decrease MMP-9 expression and invasion through inhibition of this pathway. [1] Splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. [2] Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. [3]

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>MMPResearch Areas >>CancerNatural Products >>Flavonoids

References

[1]. Yoon SO et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75.

[2]. O'Brien K et al. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28;283(48):33147-54.

[3]. Liu G et al. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.J Endocrinol. 2007 Sep;194(3):569-78.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	843.6±65.0 °C at 760 mmHg
Melting Point	355ºC
Molecular Formula	C₃₂H₂₂O₁₀
Molecular Weight	566.511
Flash Point	280.2±27.8 °C
Exact Mass	566.121277
PSA	159.80000
LogP	5.24
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.714
InChIKey	HUOOMAOYXQFIDQ-UHFFFAOYSA-N
SMILES	COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(-c5cc(=O)c6c(O)cc(O)cc6o5)ccc4OC)c3o2)cc1
Storage condition	-20°C

Synonyms

8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one

ISOGINKGETIN

4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-

4',4'''-di-O-methylamentoflavone

Recommended......