Introduction：Basic information about CAS 1910-68-5|N-METHYLISATIN-3-THIOSEMICARBAZONE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-METHYLISATIN-3-THIOSEMICARBAZONE |
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| CAS Number | 1910-68-5 | Molecular Weight | 234.28 |
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| Density | 1.47 g/cm3 | Boiling Point | 410.3ºC at 760 mmHg |
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| Molecular Formula | C10H10N4OS | Melting Point | 245° |
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| MSDS | / | Flash Point | 202ºC |
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Names
| Name | Metisazone |
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| Synonym | More Synonyms |
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N-METHYLISATIN-3-THIOSEMICARBAZONE BiologicalActivity
| Description | Methisazone (Marboran) is an antiviral agent that works by inhibiting mRNA and protein synthesis. Methisazone is also a SARS-CoV-2 (COVID-19) inhibitor. Methisazone is mainly used in pox viruses[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoV |
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| References | [1]. Bhumi Shah, et al. In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. Life Sci. 2020 Jul 1;252:117652. |
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Chemical & Physical Properties
| Density | 1.47 g/cm3 |
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| Boiling Point | 410.3ºC at 760 mmHg |
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| Melting Point | 245° |
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| Molecular Formula | C10H10N4OS |
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| Molecular Weight | 234.28 |
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| Flash Point | 202ºC |
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| Exact Mass | 234.05800 |
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| PSA | 102.81000 |
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| LogP | 1.35650 |
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| Vapour Pressure | 6.07E-07mmHg at 25°C |
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| Index of Refraction | 1.732 |
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| InChIKey | TTZUCVNWOZLIGL-UHFFFAOYSA-N |
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| SMILES | Cn1c(O)c(N=NC(N)=S)c2ccccc21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NL7960000
- CHEMICAL NAME :
- Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)
- CAS REGISTRY NUMBER :
- 1910-68-5
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H10-N4-O-S
- MOLECULAR WEIGHT :
- 234.30
- WISWESSER LINE NOTATION :
- T56 BNVYJ B1 DUNMYZUS
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >50 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Human HeLa cell
- DOSE/DURATION :
- 30 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976
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Safety Information
Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| Metisazon |
| Viruzona |
| Metisazonum |
| N-methylisatin-3-thiosemicarbazone |
| methisazone |
| [(1-methyl-2-oxoindol-3-ylidene)amino]thiourea |
| [(Z)-(1-methyl-2-oxoindol-3-ylidene)amino]thiourea |
| Marboran |
| N-Methylisatin thiosemicarbazone |
| Kemoviran |
